(6R)-7t-((R)-2-amino-2-phenyl-acetylamino)-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Ξ)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester; mono-(toluene-4-sulfonate)

Base Information

Chemical Name:(6R)-7t-((R)-2-amino-2-phenyl-acetylamino)-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Ξ)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester; mono-(toluene-4-sulfonate)
CAS No.:63491-75-8
Molecular Formula:C₇H₈O₃S*C₂₇H₂₃N₅O₆S₃
Molecular Weight:781.912
Hs Code.:

(6<i>R</i>)-7<i>t</i>-((<i>R</i>)-2-amino-2-phenyl-acetylamino)-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-(6<i>r</i><i>H</i>)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Ξ)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester; mono-(toluene-4-sulfonate)

Synonyms:(6R)-7t-((R)-2-amino-2-phenyl-acetylamino)-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Ξ)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester; mono-(toluene-4-sulfonate)

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Chemical Property of (6R)-7t-((R)-2-amino-2-phenyl-acetylamino)-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Ξ)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester; mono-(toluene-4-sulfonate)

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Technology Process of (6R)-7t-((R)-2-amino-2-phenyl-acetylamino)-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Ξ)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester; mono-(toluene-4-sulfonate)

There total 5 articles about (6R)-7t-((R)-2-amino-2-phenyl-acetylamino)-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Ξ)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester; mono-(toluene-4-sulfonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2900-27-8,3601-66-9,14675-97-9,33125-05-2
2-(tert-butoxycarbonylamino)-2-phenylacetic acid

: 63491-75-8
(6R)-7t-((R)-2-amino-2-phenyl-acetylamino)-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Ξ)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester; mono-(toluene-4-sulfonate)

Guidance literature:: Multi-step reaction with 3 steps

1: (i) monotrimethylsilylacetamide, THF, (ii) /BRN= 529873/, ClCO₂iBu

2: (i) dicyclohexylamine, (ii) /BRN= 132375/

3: acetonitrile / Ambient temperature

In acetonitrile;
DOI:10.1021/jm00219a009

Reference yield:

: 6940-49-4
3-Bromophthalide

: 63491-75-8
(6R)-7t-((R)-2-amino-2-phenyl-acetylamino)-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Ξ)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester; mono-(toluene-4-sulfonate)

Guidance literature:: Multi-step reaction with 2 steps

1: (i) dicyclohexylamine, (ii) /BRN= 132375/

2: acetonitrile / Ambient temperature

In acetonitrile;
DOI:10.1021/jm00219a009

Reference yield:

: 139975-06-7
(6R)-7t-((R)-2-tert-butoxycarbonylamino-2-phenyl-acetylamino)-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 63491-75-8
(6R)-7t-((R)-2-amino-2-phenyl-acetylamino)-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Ξ)-3-oxo-1,3-dihydro-isobenzofuran-1-yl ester; mono-(toluene-4-sulfonate)

Guidance literature:: Multi-step reaction with 2 steps

1: (i) dicyclohexylamine, (ii) /BRN= 132375/

2: acetonitrile / Ambient temperature

In acetonitrile;
DOI:10.1021/jm00219a009