Technology Process of (Z)-4-(t-butyldiphenylsilyloxy)but-2-enoic acid
There total 3 articles about (Z)-4-(t-butyldiphenylsilyloxy)but-2-enoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
cis-4-(tert-butyl-diphenylsilanyloxy)-but-2-enal;
With
sodium chlorite; sodium dihydrogenphosphate;
In
tetrahydrofuran; dimethyl sulfoxide; tert-butyl alcohol;
at 0 ℃;
for 1h;
With
hydrogenchloride;
In
tetrahydrofuran; water; dimethyl sulfoxide; tert-butyl alcohol;
pH=3;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C
1.2: 0.5 h / -78 - 0 °C
2.1: sodium chlorite; sodium dihydrogenphosphate / dimethyl sulfoxide; tert-butyl alcohol; tetrahydrofuran / 1 h / 0 °C
2.2: pH 3
With
sodium chlorite; sodium dihydrogenphosphate; oxalyl dichloride; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C
2.2: 0.5 h / -78 - 0 °C
3.1: sodium chlorite; sodium dihydrogenphosphate / dimethyl sulfoxide; tert-butyl alcohol; tetrahydrofuran / 1 h / 0 °C
3.2: pH 3
With
1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; oxalyl dichloride; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;
