8-Benzylthio-5-methoxycarbonylquinoline

Base Information

Chemical Name:8-Benzylthio-5-methoxycarbonylquinoline
CAS No.:135292-49-8
Molecular Formula:C₁₈H₁₅NO₂S
Molecular Weight:309.389
Hs Code.:

Synonyms:8-Benzylthio-5-methoxycarbonylquinoline

Suppliers and Price of 8-Benzylthio-5-methoxycarbonylquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-Benzylthio-5-methoxycarbonylquinoline

Chemical Property:

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Technology Process of 8-Benzylthio-5-methoxycarbonylquinoline

There total 8 articles about 8-Benzylthio-5-methoxycarbonylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 135292-40-9
8-Benzylthio-5-carboxyquinoline

: 135292-49-8
8-Benzylthio-5-methoxycarbonylquinoline

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; ethyl acetate; at 0 ℃;
DOI:10.1002/jhet.5570280321

Reference yield:

: 65741-91-5
5-Nitro-8-tosyloxyquinoline

: 135292-49-8
8-Benzylthio-5-methoxycarbonylquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / Et₃N / dimethylformamide / 23 h / Ambient temperature

2: 94 percent / Zn, glacial acetic acid / 1 h / Ambient temperature

3: 61 percent / NaNO₂, HBF₄ / H₂O / 0.5 h / 0 °C

4: 52 percent / cuprous cyanide / dimethylsulfoxide / 0.17 h / 20 °C

5: 54 percent / 6N HCl / 6 h / Heating

6: 100 percent / 1,5-Diazabicyclo<4.3.0>non-5-ene / methanol / 2 h / Ambient temperature

7: 60 percent / HCl / methanol; ethyl acetate; diethyl ether / 0 °C

With hydrogenchloride; tetrafluoroboric acid; DBN; copper(l) cyanide; acetic acid; triethylamine; zinc; sodium nitrite; In methanol; diethyl ether; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570280321

Reference yield:

: 4008-48-4
nitroxoline

: 135292-49-8
8-Benzylthio-5-methoxycarbonylquinoline

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / Et₃N

2: 86 percent / Et₃N / dimethylformamide / 23 h / Ambient temperature

3: 94 percent / Zn, glacial acetic acid / 1 h / Ambient temperature

4: 61 percent / NaNO₂, HBF₄ / H₂O / 0.5 h / 0 °C

5: 52 percent / cuprous cyanide / dimethylsulfoxide / 0.17 h / 20 °C

6: 54 percent / 6N HCl / 6 h / Heating

7: 100 percent / 1,5-Diazabicyclo<4.3.0>non-5-ene / methanol / 2 h / Ambient temperature

8: 60 percent / HCl / methanol; ethyl acetate; diethyl ether / 0 °C

With hydrogenchloride; tetrafluoroboric acid; DBN; copper(l) cyanide; acetic acid; triethylamine; zinc; sodium nitrite; In methanol; diethyl ether; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570280321