7-(4-bromo-phenyl)-3-methyl-5-thioxo-5,6-dihydro-[1,2,4] triazolo [4,3-c] pyrimidine-8-carbonitrile

Base Information

Chemical Name:7-(4-bromo-phenyl)-3-methyl-5-thioxo-5,6-dihydro-[1,2,4] triazolo [4,3-c] pyrimidine-8-carbonitrile
CAS No.:1488329-99-2
Molecular Formula:C₁₃H₈BrN₅S
Molecular Weight:346.21
Hs Code.:

Synonyms:7-(4-bromo-phenyl)-3-methyl-5-thioxo-5,6-dihydro-[1,2,4] triazolo [4,3-c] pyrimidine-8-carbonitrile

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Chemical Property of 7-(4-bromo-phenyl)-3-methyl-5-thioxo-5,6-dihydro-[1,2,4] triazolo [4,3-c] pyrimidine-8-carbonitrile

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Technology Process of 7-(4-bromo-phenyl)-3-methyl-5-thioxo-5,6-dihydro-[1,2,4] triazolo [4,3-c] pyrimidine-8-carbonitrile

There total 3 articles about 7-(4-bromo-phenyl)-3-methyl-5-thioxo-5,6-dihydro-[1,2,4] triazolo [4,3-c] pyrimidine-8-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1333074-73-9
6-(4-bromo-phenyl)-4-hydrazino-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile

: 108-24-7
acetic anhydride

: 1488329-99-2
7-(4-bromo-phenyl)-3-methyl-5-thioxo-5,6-dihydro-[1,2,4] triazolo [4,3-c] pyrimidine-8-carbonitrile

Guidance literature:: for 2h; Reflux;
DOI:10.1016/j.ejmech.2013.08.032

Reference yield:

: 294873-59-9
6-(4-bromophenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

: 1488329-99-2
7-(4-bromo-phenyl)-3-methyl-5-thioxo-5,6-dihydro-[1,2,4] triazolo [4,3-c] pyrimidine-8-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus pentachloride; trichlorophosphate

2: hydrazine hydrate / methanol / 0.33 h / Reflux

3: 2 h / Reflux

With phosphorus pentachloride; hydrazine hydrate; trichlorophosphate; In methanol;
DOI:10.1016/j.ejmech.2013.08.032

Reference yield:

: 1333074-60-4
C₁₁H₅BrClN₃S

: 1488329-99-2
7-(4-bromo-phenyl)-3-methyl-5-thioxo-5,6-dihydro-[1,2,4] triazolo [4,3-c] pyrimidine-8-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 0.33 h / Reflux

2: 2 h / Reflux

With hydrazine hydrate; In methanol;
DOI:10.1016/j.ejmech.2013.08.032