[(1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol

Base Information

Chemical Name:[(1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol
CAS No.:1219687-56-5
Molecular Formula:C₁₈H₂₁NO₃
Molecular Weight:299.37
Hs Code.:

Synonyms:[(1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol

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Chemical Property of [(1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol

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Technology Process of [(1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol

There total 7 articles about [(1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 57061-12-8
trans-1-phenyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid methyl ester

: 1219687-56-5
[(1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1039/c1cc13179f

Reference yield:

: (L)-3,4-dimethoxyphenylalanine methyl ester trifluoroacetate

: 1219687-56-5
[(1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; magnesium sulfate / dichloromethane; sodium chloride / 0 - 20 °C / Inert atmosphere; Molecular sieve

2: trifluoroacetic acid / 8 h / Reflux; Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; sodium hydrogencarbonate; magnesium sulfate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; sodium chloride; 2: Pictet-Spengler cyclisation;
DOI:10.1039/c1cc13179f

Reference yield:

: 70471-01-1
C₁₉H₂₁NO₄

: 1219687-56-5
[(1R,3S)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinolin-3-yl]methanol

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 8 h / Reflux; Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; trifluoroacetic acid; In tetrahydrofuran; 1: Pictet-Spengler cyclisation;
DOI:10.1039/c1cc13179f