(4-fluorophenyl)(4-(1-trityl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanol

Base Information

Chemical Name:(4-fluorophenyl)(4-(1-trityl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanol
CAS No.:1362690-46-7
Molecular Formula:C₃₇H₂₈FN₅O
Molecular Weight:577.661
Hs Code.:

Synonyms:(4-fluorophenyl)(4-(1-trityl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanol

Suppliers and Price of (4-fluorophenyl)(4-(1-trityl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanol

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Chemical Property of (4-fluorophenyl)(4-(1-trityl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanol

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Technology Process of (4-fluorophenyl)(4-(1-trityl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanol

There total 5 articles about (4-fluorophenyl)(4-(1-trityl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 197913-15-8
4-amino-1-triphenylmethylimidazole

: 1241914-72-6
(4-chloroquinazoline-2-yl)(4-fluorophenyl)methanone

: 1362690-46-7
(4-fluorophenyl)(4-(1-trityl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanol

Guidance literature:: 4-amino-1-triphenylmethylimidazole; (4-chloroquinazoline-2-yl)(4-fluorophenyl)methanone; With triethylamine; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

With methanol; sodium tetrahydroborate; In ethanol; at 0 ℃; for 0.333333h;

In ethanol; ethyl acetate; for 0.75h;

Reference yield:

: 76-83-5
trityl chloride

: 1362690-46-7
(4-fluorophenyl)(4-(1-trityl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

1.2: Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 2.67 h / 20 - 50 °C

3.1: potassium iodide; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

3.2: 0.33 h / 0 °C

3.3: 0.75 h

With hydrogen; triethylamine; potassium iodide; palladium 10% on activated carbon; In ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 173865-33-3
4-nitro-1-triphenylmethylimidazole

: 1362690-46-7
(4-fluorophenyl)(4-(1-trityl-1H-imidazol-4-ylamino)quinazolin-2-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 2.67 h / 20 - 50 °C

2.1: potassium iodide; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

2.2: 0.33 h / 0 °C

2.3: 0.75 h

With hydrogen; triethylamine; potassium iodide; palladium 10% on activated carbon; In ethanol; ethyl acetate; N,N-dimethyl-formamide;