(Z)-benzyl 2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrole-4-carboxylate hydrobromide

Base Information

• Chemical Name: (Z)-benzyl 2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrole-4-carboxylate hydrobromide
• CAS No.: 1613187-19-1
• Molecular Formula: BrH*C₂₁H₂₂N₂O₂
• Molecular Weight: 415.33
• Mol file: 1613187-19-1.mol

Synonyms:(Z)-benzyl 2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrole-4-carboxylate hydrobromide

Chemical Property of (Z)-benzyl 2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrole-4-carboxylate hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-benzyl 2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrole-4-carboxylate hydrobromide

There total 2 articles about (Z)-benzyl 2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrole-4-carboxylate hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,5-dimethylpyrrole-2-carbaldehyde (2199-58-8) + benzyl 2,4-dimethyl-1H-pyrrole-3-carboxylate (37059-10-2) → (Z)-benzyl 2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrole-4-carboxylate hydrobromide (1613187-19-1)

Guidance literature:

With hydrogen bromide; In tetrahydrofuran; methanol; at 0 ℃; for 1h;

DOI:10.1039/c3ob42548g

Reference yield:

3,5-dimethyl-1H-pyrrole-2, 4-dicarboxylic acid 2-tert-butyl ester 4-benzyl ester (89909-48-8) → (Z)-benzyl 2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrole-4-carboxylate hydrobromide (1613187-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane

2: hydrogen bromide / tetrahydrofuran; methanol / 1 h / 0 °C

With hydrogen bromide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1039/c3ob42548g

Reference yield: 68.0%

(Z)-benzyl 2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrole-4-carboxylate hydrobromide (1613187-19-1) + zinc(II) acetate dihydrate (5970-45-6) → C42H42N4O4Zn (1613187-23-7)

Guidance literature:

With sodium acetate; In methanol; chloroform; at 20 ℃; for 5h;

DOI:10.1039/c3ob42548g

upstream raw materials:

3,5-dimethylpyrrole-2-carbaldehyde

benzyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

3,5-dimethyl-1H-pyrrole-2, 4-dicarboxylic acid 2-tert-butyl ester 4-benzyl ester

Downstream raw materials:

C₄₂H₄₂N₄O₄Zn

Refernces