(+)-tert-butyl (1S,2S)-2-(N-chloro-N-(mesitylmethyl)amino)cyclopentanecarboxylate

Base Information

Chemical Name:(+)-tert-butyl (1S,2S)-2-(N-chloro-N-(mesitylmethyl)amino)cyclopentanecarboxylate
CAS No.:909786-18-1
Molecular Formula:C₂₀H₃₀ClNO₂
Molecular Weight:351.917
Hs Code.:

Synonyms:(+)-tert-butyl (1S,2S)-2-(N-chloro-N-(mesitylmethyl)amino)cyclopentanecarboxylate

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Chemical Property of (+)-tert-butyl (1S,2S)-2-(N-chloro-N-(mesitylmethyl)amino)cyclopentanecarboxylate

Chemical Property:

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Technology Process of (+)-tert-butyl (1S,2S)-2-(N-chloro-N-(mesitylmethyl)amino)cyclopentanecarboxylate

There total 4 articles about (+)-tert-butyl (1S,2S)-2-(N-chloro-N-(mesitylmethyl)amino)cyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 909786-12-5
(+)-tert-butyl (1S,2S)-2-((mesitylmethyl)amino)cyclopentanecarboxylate

: 909786-18-1
(+)-tert-butyl (1S,2S)-2-(N-chloro-N-(mesitylmethyl)amino)cyclopentanecarboxylate

Guidance literature:: With N-chloro-succinimide; In dichloromethane; at -20 ℃;
DOI:10.1016/j.tet.2006.06.040

Reference yield:

: 909849-55-4
N-(mesitylmethyl)-N-(trimethylsilyl)amine

: 909786-18-1
(+)-tert-butyl (1S,2S)-2-(N-chloro-N-(mesitylmethyl)amino)cyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: n-BuLi; (-)-(R,R)-(CH₃OCH(Ph))2 / toluene; hexane / 1.5 h / -78 °C

2: 95 percent / NCS / CH₂Cl₂ / -20 °C

With N-chloro-succinimide; n-butyllithium; (1R,2R)-1,2-diphenyl-1,2-dimethoxyethane; In hexane; dichloromethane; toluene;
DOI:10.1016/j.tet.2006.06.040

Reference yield:

: 40393-99-5
(2,4,6-trimethylbenzyl)amine

: 909786-18-1
(+)-tert-butyl (1S,2S)-2-(N-chloro-N-(mesitylmethyl)amino)cyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / n-BuLi / tetrahydrofuran / -78 - 20 °C

2: n-BuLi; (-)-(R,R)-(CH₃OCH(Ph))2 / toluene; hexane / 1.5 h / -78 °C

3: 95 percent / NCS / CH₂Cl₂ / -20 °C

With N-chloro-succinimide; n-butyllithium; (1R,2R)-1,2-diphenyl-1,2-dimethoxyethane; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1016/j.tet.2006.06.040