7-(3-fluoro-5-methylcarbamoyl-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carboxylic acid

Base Information

Chemical Name:7-(3-fluoro-5-methylcarbamoyl-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carboxylic acid
CAS No.:1046451-74-4
Molecular Formula:C₁₉H₁₈FNO₄
Molecular Weight:343.355
Hs Code.:

Synonyms:7-(3-fluoro-5-methylcarbamoyl-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carboxylic acid

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Chemical Property of 7-(3-fluoro-5-methylcarbamoyl-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carboxylic acid

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Technology Process of 7-(3-fluoro-5-methylcarbamoyl-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carboxylic acid

There total 1 articles about 7-(3-fluoro-5-methylcarbamoyl-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1046451-73-3
7-(3-fluoro-5-methylcarbamoyl-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carboxylic acid methyl ester

: 1046451-74-4
7-(3-fluoro-5-methylcarbamoyl-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carboxylic acid

Guidance literature:: 7-(3-fluoro-5-methylcarbamoyl-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carboxylic acid methyl ester; With potassium hydroxide; In methanol; at 20 ℃;

With hydrogenchloride; In water;

Reference yield: 88.0%

: 1046451-74-4
7-(3-fluoro-5-methylcarbamoyl-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carboxylic acid

: 14907-27-8,5619-09-0,7524-52-9,26988-71-6,41222-70-2,67557-19-1,109492-62-8
(R)-(+)-tryptophan methyl ester hydrochloride

: (R)-2-{[7-(3-fluoro-5-methylcarbamoyl-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carbonyl]-amino}-3-(1H-indol-3-yl)-propionic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield: 78.0%

: 925940-12-1
2-amino-3-(5,6-difluoro-1H-indol-3-yl)-propionic acid ethyl ester hydrochloride

: 1046451-74-4
7-(3-fluoro-5-methylcarbamoyl-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carboxylic acid

: 1033765-76-2
3-(5,6-difluoro-1H-indol-3-yl)-2-{[7-(3-fluoro-5-methylcarbamoyl-phenyl)-2,3,4,5-tetrahydro-benzo[b]oxepine-9-carbonyl]-amino}-propionic acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;