benzyl 7-aza-7-(benzyloxycarbonyl)-2(S)-<(benzyloxycarbonyl)amino>-11-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)undecanoate

Base Information

Chemical Name:benzyl 7-aza-7-(benzyloxycarbonyl)-2(S)-<(benzyloxycarbonyl)amino>-11-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)undecanoate
CAS No.:143565-75-7
Molecular Formula:C₅₀H₅₇N₅O₇
Molecular Weight:840.032
Hs Code.:

Synonyms:benzyl 7-aza-7-(benzyloxycarbonyl)-2(S)-<(benzyloxycarbonyl)amino>-11-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)undecanoate

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Chemical Property of benzyl 7-aza-7-(benzyloxycarbonyl)-2(S)-<(benzyloxycarbonyl)amino>-11-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)undecanoate

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Technology Process of benzyl 7-aza-7-(benzyloxycarbonyl)-2(S)-<(benzyloxycarbonyl)amino>-11-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)undecanoate

There total 8 articles about benzyl 7-aza-7-(benzyloxycarbonyl)-2(S)-<(benzyloxycarbonyl)amino>-11-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)undecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: (S)-2-Benzyloxycarbonylamino-6-[4-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-butylamino]-hexanoic acid benzyl ester

: 143565-75-7
benzyl 7-aza-7-(benzyloxycarbonyl)-2(S)-<(benzyloxycarbonyl)amino>-11-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)undecanoate

Guidance literature:: With sodium carbonate; In tetrahydrofuran; water; for 2h;
DOI:10.1021/jo00049a036

Reference yield:

: 1466-67-7
1,3-dibenzylurea

: 143565-75-7
benzyl 7-aza-7-(benzyloxycarbonyl)-2(S)-<(benzyloxycarbonyl)amino>-11-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)undecanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1) i-Pr₂NEt / 1) H₂O, 10 min, 2) EtOAc, reflux

2: 85 percent / LiBH₄ / tetrahydrofuran / Heating

3: 1) (COCl)2, DMSO, 2) i-Pr₂NEt / 1) CH₂Cl₂, T < -50 deg C, 20 min, 2) -50 to 0 deg C

5: 74 percent / Na₂CO₃ / tetrahydrofuran; H₂O / 2 h

With lithium borohydride; oxalyl dichloride; sodium carbonate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water;
DOI:10.1021/jo00049a036

Reference yield:

: 130750-14-0
4-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)butyraldehyde

: 143565-75-7
benzyl 7-aza-7-(benzyloxycarbonyl)-2(S)-<(benzyloxycarbonyl)amino>-11-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)undecanoate

Guidance literature:: Multi-step reaction with 2 steps

2: 74 percent / Na₂CO₃ / tetrahydrofuran; H₂O / 2 h

With sodium carbonate; In tetrahydrofuran; water;
DOI:10.1021/jo00049a036