(rac)-N-(4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)isobutyramide

Base Information

Chemical Name:(rac)-N-(4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)isobutyramide
CAS No.:1469978-70-8
Molecular Formula:C₂₀H₂₁N₃O
Molecular Weight:319.406
Hs Code.:

Synonyms:(rac)-N-(4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)isobutyramide

Suppliers and Price of (rac)-N-(4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)isobutyramide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (rac)-N-(4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)isobutyramide

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Technology Process of (rac)-N-(4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)isobutyramide

There total 7 articles about (rac)-N-(4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1469978-59-3
(rac)-4-(8-amino-5,6,7,8-tetrahydroisoquinolin-4-yl)benzonitrile

: 79-30-1
isobutyryl chloride

: 1469978-70-8
(rac)-N-(4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)isobutyramide

Guidance literature:: With triethylamine; In dichloromethane; at -20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b00851

Reference yield: 63.0%

: 1469978-70-8
(rac)-N-(4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)isobutyramide

Guidance literature:: With triethylamine; In dichloromethane; at -20 ℃; for 0.583333h; Inert atmosphere;

Reference yield:

: 1428651-85-7
(rac)-methyl 4-bromo-8-oxo-5,6,7,8-tetrahydroisoquinoline-7-carboxylate

: 1469978-70-8
(rac)-N-(4-(4-cyanophenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)isobutyramide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 2.5 h / Reflux; Inert atmosphere

2.1: titanium(IV) isopropylate; ammonia / methanol / 5 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; ethanol / 16 h / 85 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0.5 h / -20 °C / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; sodium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water;
DOI:10.1021/acs.jmedchem.5b00851