(1R,2'S)-1-(1'-methyl-2'-pyrrolidinyl)-2-(o-methoxyethoxymethoxy-p-bromophenoxy)ethanol

Base Information

Chemical Name:(1R,2'S)-1-(1'-methyl-2'-pyrrolidinyl)-2-(o-methoxyethoxymethoxy-p-bromophenoxy)ethanol
CAS No.:1338384-55-6
Molecular Formula:C₁₇H₂₆BrNO₅
Molecular Weight:404.301
Hs Code.:

Synonyms:(1R,2'S)-1-(1'-methyl-2'-pyrrolidinyl)-2-(o-methoxyethoxymethoxy-p-bromophenoxy)ethanol

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Chemical Property of (1R,2'S)-1-(1'-methyl-2'-pyrrolidinyl)-2-(o-methoxyethoxymethoxy-p-bromophenoxy)ethanol

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Technology Process of (1R,2'S)-1-(1'-methyl-2'-pyrrolidinyl)-2-(o-methoxyethoxymethoxy-p-bromophenoxy)ethanol

There total 5 articles about (1R,2'S)-1-(1'-methyl-2'-pyrrolidinyl)-2-(o-methoxyethoxymethoxy-p-bromophenoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1338384-49-8
(S)-N-Cbz-2-(o-methoxyethoxymethoxy-p-bromophenoxyacetyl)pyrrolidine

: 1338384-56-7
(1S,2'S)-1-(1'-methyl-2'-pyrrolidinyl)-2-(o-methoxyethoxymethoxy-p-bromophenoxy)ethanol

: 1338384-55-6
(1R,2'S)-1-(1'-methyl-2'-pyrrolidinyl)-2-(o-methoxyethoxymethoxy-p-bromophenoxy)ethanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -20 - -10 ℃;
DOI:10.1021/jm200937t

Reference yield:

: 30186-18-6
4'-bromo-2'-hydroxyacetophenone

: 1338384-55-6
(1R,2'S)-1-(1'-methyl-2'-pyrrolidinyl)-2-(o-methoxyethoxymethoxy-p-bromophenoxy)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 4 h / 0 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

3.1: sodium hydroxide / methanol

3.2: 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - -10 °C

With lithium aluminium tetrahydride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; 2.1: Dakin reaction / 2.2: Dakin reaction;
DOI:10.1021/jm200937t

Reference yield:

: 223785-66-8
2-(S)-(2-bromo-1-oxoethyl)pyrrolidine-1-carboxylic acid benzyl ester

: 1338384-55-6
(1R,2'S)-1-(1'-methyl-2'-pyrrolidinyl)-2-(o-methoxyethoxymethoxy-p-bromophenoxy)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol

1.2: 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - -10 °C

With lithium aluminium tetrahydride; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1021/jm200937t