1-Methyl-2-<(1S)-1-(2,6-dichlorophenyl)ethyl>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 1-Methyl-2-<(1S)-1-(2,6-dichlorophenyl)ethyl>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 121443-95-6
• Molecular Formula: C₂₀H₂₃Cl₂NO₂
• Molecular Weight: 380.314

Synonyms:1-Methyl-2-<(1S)-1-(2,6-dichlorophenyl)ethyl>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 1-Methyl-2-<(1S)-1-(2,6-dichlorophenyl)ethyl>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of 1-Methyl-2-<(1S)-1-(2,6-dichlorophenyl)ethyl>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about 1-Methyl-2-<(1S)-1-(2,6-dichlorophenyl)ethyl>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(S)-1-(2,6-Dichloro-phenyl)-ethyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-isoquinolinium; GENERIC INORGANIC ANION → (R)-2-[(S)-1-(2,6-Dichloro-phenyl)-ethyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline (128592-54-1) + 1-Methyl-2-<(1S)-1-(2,6-dichlorophenyl)ethyl>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (121443-95-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; at -78 ℃; for 4h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00195a044

Reference yield:

(S)-N-<2-(3,4-Dimethoxyphenyl)ethyl>-1-(2,6-dichlorophenyl)ethylamine (121443-83-2) → 1-Methyl-2-<(1S)-1-(2,6-dichlorophenyl)ethyl>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (121443-95-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent

2: phosphorus oxytrichloride / benzene / Heating

3: 1.) Mg / 2.) THF, -78 deg C

With magnesium; trichlorophosphate; In benzene;

DOI:10.1016/S0040-4039(00)94630-6

Reference yield:

N-[(S)-1-(2,6-Dichloro-phenyl)-ethyl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-formamide (128592-47-2) → 1-Methyl-2-<(1S)-1-(2,6-dichlorophenyl)ethyl>-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (121443-95-6)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus oxytrichloride / benzene / Heating

2: 1.) Mg / 2.) THF, -78 deg C

With magnesium; trichlorophosphate; In benzene;

DOI:10.1016/S0040-4039(00)94630-6

upstream raw materials:

methyl bromide

(S)-N-<2-(3,4-Dimethoxyphenyl)ethyl>-1-(2,6-dichlorophenyl)ethylamine

N-[(S)-1-(2,6-Dichloro-phenyl)-ethyl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-formamide

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