N-((benzylcarbamoyl)oxy)-3-(2,4-dichlorophenyl)-5-(4-fluorophenethoxy)pentanamide

Base Information

Chemical Name:N-((benzylcarbamoyl)oxy)-3-(2,4-dichlorophenyl)-5-(4-fluorophenethoxy)pentanamide
CAS No.:1551577-93-5
Molecular Formula:C₂₇H₂₇Cl₂FN₂O₄
Molecular Weight:533.427
Hs Code.:

Synonyms:N-((benzylcarbamoyl)oxy)-3-(2,4-dichlorophenyl)-5-(4-fluorophenethoxy)pentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((benzylcarbamoyl)oxy)-3-(2,4-dichlorophenyl)-5-(4-fluorophenethoxy)pentanamide

Chemical Property:

Purity/Quality:

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Technology Process of N-((benzylcarbamoyl)oxy)-3-(2,4-dichlorophenyl)-5-(4-fluorophenethoxy)pentanamide

There total 12 articles about N-((benzylcarbamoyl)oxy)-3-(2,4-dichlorophenyl)-5-(4-fluorophenethoxy)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₁₈Cl₂FNO₄

: 100-46-9
benzylamine

: 1551577-93-5
N-((benzylcarbamoyl)oxy)-3-(2,4-dichlorophenyl)-5-(4-fluorophenethoxy)pentanamide

Guidance literature:: In acetonitrile; at 20 ℃;
DOI:10.1016/j.bmc.2013.11.053

Reference yield:

: 7589-27-7
2-(4-Fluorophenyl)ethanol

: 1551577-93-5
N-((benzylcarbamoyl)oxy)-3-(2,4-dichlorophenyl)-5-(4-fluorophenethoxy)pentanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2,6-dimethylpyridine / chloroform / 1 h / 0 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: Jones reagent / acetic acid / 1 h / 0 - 20 °C

4.1: tetrahydrofuran; diethyl ether / 0 °C

5.1: potassium cyanide; hydroxylamine / tetrahydrofuran; water; methanol / 20 °C

6.1: acetonitrile / 0.5 h / 0 °C

7.1: acetonitrile / 20 °C

With 2,6-dimethylpyridine; potassium cyanide; Jones reagent; hydroxylamine; sodium hydride; In tetrahydrofuran; methanol; diethyl ether; chloroform; water; acetic acid; acetonitrile;
DOI:10.1016/j.bmc.2013.11.053

Reference yield:

: 74299-82-4
dimethyl 2-(2,4-dichlorobenzylidene)malonate

: 1551577-93-5
N-((benzylcarbamoyl)oxy)-3-(2,4-dichlorophenyl)-5-(4-fluorophenethoxy)pentanamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium methylate / methanol / 1 h / 20 °C

2.1: hydrogenchloride; water / Reflux

3.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / -78 - 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 0 - 20 °C

5.1: Jones reagent / acetic acid / 1 h / 0 - 20 °C

6.1: tetrahydrofuran; diethyl ether / 0 °C

7.1: potassium cyanide; hydroxylamine / tetrahydrofuran; water; methanol / 20 °C

8.1: acetonitrile / 0.5 h / 0 °C

9.1: acetonitrile / 20 °C

With hydrogenchloride; potassium cyanide; Jones reagent; dimethylsulfide borane complex; water; hydroxylamine; sodium methylate; sodium hydride; In tetrahydrofuran; methanol; diethyl ether; water; acetic acid; acetonitrile; 1.1: |Michael Addition;
DOI:10.1016/j.bmc.2013.11.053