(R)-2-tert-Butoxycarbonylamino-6-[((R)-3-{(S)-2-[6-(diphenoxy-phosphoryloxy)-hexanoylamino]-propionylamino}-3-methoxycarbonyl-propyl)-methoxy-phosphinoylmethyl]-heptanedioic acid dimethyl ester

Base Information

• Chemical Name: (R)-2-tert-Butoxycarbonylamino-6-[((R)-3-{(S)-2-[6-(diphenoxy-phosphoryloxy)-hexanoylamino]-propionylamino}-3-methoxycarbonyl-propyl)-methoxy-phosphinoylmethyl]-heptanedioic acid dimethyl ester
• CAS No.: 219752-73-5
• Molecular Formula: C₄₂H₆₃N₃O₁₆P₂
• Molecular Weight: 927.92
• Mol file: 219752-73-5.mol

Synonyms:(R)-2-tert-Butoxycarbonylamino-6-[((R)-3-{(S)-2-[6-(diphenoxy-phosphoryloxy)-hexanoylamino]-propionylamino}-3-methoxycarbonyl-propyl)-methoxy-phosphinoylmethyl]-heptanedioic acid dimethyl ester

Chemical Property of (R)-2-tert-Butoxycarbonylamino-6-[((R)-3-{(S)-2-[6-(diphenoxy-phosphoryloxy)-hexanoylamino]-propionylamino}-3-methoxycarbonyl-propyl)-methoxy-phosphinoylmethyl]-heptanedioic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-tert-Butoxycarbonylamino-6-[((R)-3-{(S)-2-[6-(diphenoxy-phosphoryloxy)-hexanoylamino]-propionylamino}-3-methoxycarbonyl-propyl)-methoxy-phosphinoylmethyl]-heptanedioic acid dimethyl ester

There total 6 articles about (R)-2-tert-Butoxycarbonylamino-6-[((R)-3-{(S)-2-[6-(diphenoxy-phosphoryloxy)-hexanoylamino]-propionylamino}-3-methoxycarbonyl-propyl)-methoxy-phosphinoylmethyl]-heptanedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-(2-S-propanoic acid)-6-<(diphenoxyphosphinyl)oxy>hexanamide (219752-72-4) + (R)-2-[((R)-3-Amino-3-methoxycarbonyl-propyl)-methoxy-phosphinoylmethyl]-6-tert-butoxycarbonylamino-heptanedioic acid dimethyl ester → (R)-2-tert-Butoxycarbonylamino-6-[((R)-3-{(S)-2-[6-(diphenoxy-phosphoryloxy)-hexanoylamino]-propionylamino}-3-methoxycarbonyl-propyl)-methoxy-phosphinoylmethyl]-heptanedioic acid dimethyl ester (219752-73-5)

Guidance literature:

With 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; for 20h; Ambient temperature;

DOI:10.1021/jo981895p

Reference yield:

(R)-2-[((R)-3-Benzyloxycarbonylamino-3-methoxycarbonyl-propyl)-methoxy-phosphinoylmethyl]-6-tert-butoxycarbonylamino-heptanedioic acid dimethyl ester (219752-71-3) → (R)-2-tert-Butoxycarbonylamino-6-[((R)-3-{(S)-2-[6-(diphenoxy-phosphoryloxy)-hexanoylamino]-propionylamino}-3-methoxycarbonyl-propyl)-methoxy-phosphinoylmethyl]-heptanedioic acid dimethyl ester (219752-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 mg / H₂ / Pd/C / methanol / 10 h / Ambient temperature

2: 86 percent / 1-hydroxybenzotriazole monohydrate, dicyclohexylcarbodiimide / dimethylformamide; CH₂Cl₂ / 20 h / Ambient temperature

With hydrogen; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo981895p

Reference yield:

hexahydro-2H-oxepin-2-one (502-44-3,24980-41-4,80137-66-2) → (R)-2-tert-Butoxycarbonylamino-6-[((R)-3-{(S)-2-[6-(diphenoxy-phosphoryloxy)-hexanoylamino]-propionylamino}-3-methoxycarbonyl-propyl)-methoxy-phosphinoylmethyl]-heptanedioic acid dimethyl ester (219752-73-5)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. NaOH / 2 h / Heating

2: 83 percent / pyridine / 12 h / Ambient temperature

3: 0.87 g / 1-hydroxybenzotriazole monohydrate, 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate, pyridine / dimethylformamide; CH₂Cl₂ / 24 h / Ambient temperature

4: formic acid / 48 h / Ambient temperature

5: 86 percent / 1-hydroxybenzotriazole monohydrate, dicyclohexylcarbodiimide / dimethylformamide; CH₂Cl₂ / 20 h / Ambient temperature

With pyridine; sodium hydroxide; formic acid; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In pyridine; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo981895p

upstream raw materials:

N-(2-S-propanoic acid)-6-<(diphenoxyphosphinyl)oxy>hexanamide

hexahydro-2H-oxepin-2-one

6-hydroxyhexanoic acid sodium salt

6-(diphenoxyphosphoryloxy)hexanoic acid