4-[(5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1Hindazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclohexanecarboxylic acid

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Chemical Name:4-[(5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1Hindazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclohexanecarboxylic acid
CAS No.:1351615-90-1
Molecular Formula:C₂₇H₂₄F₃N₃O₅S
Molecular Weight:559.566
Hs Code.:

Synonyms:4-[(5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1Hindazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclohexanecarboxylic acid

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Chemical Property of 4-[(5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1Hindazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclohexanecarboxylic acid

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Technology Process of 4-[(5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1Hindazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclohexanecarboxylic acid

There total 3 articles about 4-[(5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1Hindazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1351617-39-4
4-[(5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclohexanecarboxylic acid ethyl ester

: 1351615-90-1
4-[(5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1Hindazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclohexanecarboxylic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 95 ℃; for 24h;
DOI:10.1016/j.ejmech.2017.07.015

Reference yield:

: 916420-86-5
4-methoxy-2-(trifluoromethyl)benzyl bromide

: 1351615-90-1
4-[(5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1Hindazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

2: ammonium acetate; acetic acid / 12 h / 110 °C

3: hydrogenchloride / 1,4-dioxane; water / 24 h / 95 °C

With hydrogenchloride; ammonium acetate; caesium carbonate; acetic acid; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2017.07.015

Reference yield:

: 3618-04-0,75877-66-6,17159-80-7
4-hydroxycyclohexyl carboxylic acid ethyl ester

: 1351615-90-1
4-[(5Z)-5-({1-[4-methoxy-2-(trifluoromethyl)benzyl]-1Hindazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 70 °C

2: ammonium acetate; acetic acid / 12 h / 110 °C

3: hydrogenchloride / 1,4-dioxane; water / 24 h / 95 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; ammonium acetate; acetic acid; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; water; 1: |Mitsunobu Displacement;
DOI:10.1016/j.ejmech.2017.07.015