tert-butyl 4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidine-1-carboxylate
CAS No.:1428478-80-1
Molecular Formula:C₁₉H₂₅NO₅
Molecular Weight:347.411
Hs Code.:

Synonyms:tert-butyl 4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidine-1-carboxylate

There total 13 articles about tert-butyl 4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55104-35-3
5-hydroxy-2-benzofuran-1-(3H)-one

: 161975-39-9
tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate

: 1428478-80-1
tert-butyl 4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidine-1-carboxylate

: C₂₀H₂₉NO₆

Guidance literature:: 5-hydroxy-2-benzofuran-1-(3H)-one; tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate; With sodium hydride; sodium iodide; In N,N-dimethyl-formamide; mineral oil; at 20 - 55 ℃; for 88h;

With diazomethyl-trimethyl-silane; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 55104-35-3
5-hydroxy-2-benzofuran-1-(3H)-one

: 161975-39-9
tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate

: 1428478-80-1
tert-butyl 4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidine-1-carboxylate

: C₁₉H₂₇NO₆

: C₂₀H₂₉NO₆

Guidance literature:: With sodium hexamethyldisilazane; In N,N-dimethyl-formamide; mineral oil; at 55 - 65 ℃; for 9h;

Reference yield:

: 1428478-76-5
tert-butyl 4-tert-butoxy-2-methylbenzoate

: 1428478-80-1
tert-butyl 4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidine-1-carboxylate

: C₂₀H₂₉NO₆

Guidance literature:: Multi-step reaction with 4 steps

1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; dibenzoyl peroxide / tetrachloromethane / 0.5 h / 90 °C / Inert atmosphere

2: silver nitrate / 1,4-dioxane; water / 72 h / 20 °C

3: hydrogenchloride / diethyl ether / 120 h

4: sodium hydride; sodium iodide / N,N-dimethyl-formamide; mineral oil / 88 h / 20 - 55 °C

With hydrogenchloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium hydride; silver nitrate; sodium iodide; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane; diethyl ether; water; N,N-dimethyl-formamide; mineral oil;