(R)-4-((1-(3-fluoro-5-methylphenyl)-2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)ethyl)amino)butanoic acid

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Chemical Name:(R)-4-((1-(3-fluoro-5-methylphenyl)-2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)ethyl)amino)butanoic acid
CAS No.:1308378-96-2
Molecular Formula:C₃₆H₃₇F₈N₅O₅
Molecular Weight:771.708
Hs Code.:

(R)-4-((1-(3-fluoro-5-methylphenyl)-2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)ethyl)amino)butanoic acid

Synonyms:(R)-4-((1-(3-fluoro-5-methylphenyl)-2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)ethyl)amino)butanoic acid

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Chemical Property of (R)-4-((1-(3-fluoro-5-methylphenyl)-2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)ethyl)amino)butanoic acid

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Technology Process of (R)-4-((1-(3-fluoro-5-methylphenyl)-2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)ethyl)amino)butanoic acid

There total 9 articles about (R)-4-((1-(3-fluoro-5-methylphenyl)-2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)ethyl)amino)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₈H₄₁F₈N₅O₅

: 1308378-96-2
(R)-4-((1-(3-fluoro-5-methylphenyl)-2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)ethyl)amino)butanoic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; for 3h; Heating;
DOI:10.1016/j.ejmech.2017.12.095

Reference yield:

: 1308380-33-7
1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione

: 1308378-96-2
(R)-4-((1-(3-fluoro-5-methylphenyl)-2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)ethyl)amino)butanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 50 °C

2: potassium carbonate / N,N-dimethyl-formamide / 70 °C

3: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; sodium iodide / acetonitrile / 95 °C

5: sodium hydroxide / ethanol; water / 3 h / Heating

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; sodium hydroxide; In ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2017.12.095

Reference yield:

: C₃₇H₃₉F₈N₅O₅

: 1308378-96-2
(R)-4-((1-(3-fluoro-5-methylphenyl)-2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)ethyl)amino)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; sodium iodide / acetonitrile / 95 °C

3: sodium hydroxide / ethanol; water / 3 h / Heating

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; sodium hydroxide; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.ejmech.2017.12.095