N₁-[3-({[3-chloro-3-(methyloxy)-4-biphenylyl]sulfonyl}amino)-4-(methyloxy)phenyl]-N₂-methyl-L-alaninamide hydrochloride

Base Information

• Chemical Name: N₁-[3-({[3-chloro-3-(methyloxy)-4-biphenylyl]sulfonyl}amino)-4-(methyloxy)phenyl]-N₂-methyl-L-alaninamide hydrochloride
• CAS No.: 953392-35-3
• Molecular Formula: C₂₄H₂₆ClN₃O₅S*ClH
• Molecular Weight: 540.467

Synonyms:N₁-[3-({[3-chloro-3-(methyloxy)-4-biphenylyl]sulfonyl}amino)-4-(methyloxy)phenyl]-N₂-methyl-L-alaninamide hydrochloride

Chemical Property of N₁-[3-({[3-chloro-3-(methyloxy)-4-biphenylyl]sulfonyl}amino)-4-(methyloxy)phenyl]-N₂-methyl-L-alaninamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N₁-[3-({[3-chloro-3-(methyloxy)-4-biphenylyl]sulfonyl}amino)-4-(methyloxy)phenyl]-N₂-methyl-L-alaninamide hydrochloride

There total 5 articles about N₁-[3-({[3-chloro-3-(methyloxy)-4-biphenylyl]sulfonyl}amino)-4-(methyloxy)phenyl]-N₂-methyl-L-alaninamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl ((1S)-2-{[3-({[3-chloro-3'-(methyloxy)-4-biphenylyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate (953391-90-7) → N1-[3-({[3-chloro-3-(methyloxy)-4-biphenylyl]sulfonyl}amino)-4-(methyloxy)phenyl]-N2-methyl-L-alaninamide hydrochloride (953392-35-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 1h;

Reference yield:

N-[5-amino-2-(methyloxy)phenyl]-4-bromo-2-chlorobenzenesulfonamide (953391-74-7) → N1-[3-({[3-chloro-3-(methyloxy)-4-biphenylyl]sulfonyl}amino)-4-(methyloxy)phenyl]-N2-methyl-L-alaninamide hydrochloride (953392-35-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C

1.2: 20 °C

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / Microwave irradiation

3.1: hydrogenchloride / 1,4-dioxane / 1 h

With hydrogenchloride; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

1,1-dimethylethyl ((1S)-2-{[3-{[(2-chlorophenyl)sulfonyl]amino}-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate (953391-89-4) → N1-[3-({[3-chloro-3-(methyloxy)-4-biphenylyl]sulfonyl}amino)-4-(methyloxy)phenyl]-N2-methyl-L-alaninamide hydrochloride (953392-35-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / Microwave irradiation

2: hydrogenchloride / 1,4-dioxane / 1 h

With hydrogenchloride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; 1,2-dimethoxyethane; water;

upstream raw materials:

1,1-dimethylethyl ((1S)-2-{[3-({[3-chloro-3'-(methyloxy)-4-biphenylyl]sulfonyl}amino)-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

N-[5-amino-2-(methyloxy)phenyl]-4-bromo-2-chlorobenzenesulfonamide

1,1-dimethylethyl ((1S)-2-{[3-{[(2-chlorophenyl)sulfonyl]amino}-4-(methyloxy)phenyl]amino}-1-methyl-2-oxoethyl)methylcarbamate

4-bromo-2-chlorobenzene-1-sulfonyl chloride

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