CHASMANINE

Base Information

• Chemical Name: CHASMANINE
• CAS No.: 5066-78-4
• Molecular Formula: C₂₅H₄₁NO₆
• Molecular Weight: 451.604
• Mol file: 5066-78-4.mol

Synonyms:Toroko base II;Chasmanin;

Chemical Property of CHASMANINE

Chemical Property:

• Vapor Pressure: 1.58E-14mmHg at 25°C
• Melting Point: 90-91oC
• Boiling Point: 552.9°Cat760mmHg
• Flash Point: 288.2°C
• PSA: 80.62000
• Density: 1.26g/cm³
• LogP: 1.09400

Purity/Quality:

98%,99%, ^*data from raw suppliers

Chasmanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Chasmanine is an agonist of β2 adrenergic receptor useful in the treatment of heart failure.

Technology Process of CHASMANINE

There total 1 articles about CHASMANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Foresaconitin (73870-35-6) → 4-methoxybenzoic acid (100-09-4) + Chasmanin (5066-78-4,66276-68-4,123795-79-9)

Guidance literature:

With sodium hydroxide; for 4h; Heating;

Reference yield:

chasmanine (5066-78-4,66276-68-4,123795-79-9) → anisoezochasmaconitine

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / TFA

2: p-TsOH*H₂O / toluene / 12 h / Heating

With toluene-4-sulfonic acid; trifluoroacetic acid; In toluene;

Reference yield:

chasmanine (5066-78-4,66276-68-4,123795-79-9) → 8-benzoyl-14-acetyl-Δ15,16-demethoxychasmanine

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / TFA

2: 39 percent / p-TsOH*H₂O / toluene / 12 h / Heating

With toluene-4-sulfonic acid; trifluoroacetic acid; In toluene;

upstream raw materials:

Foresaconitin

Refernces