N-(3-cyano-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Base Information

Chemical Name:N-(3-cyano-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide
CAS No.:1360622-16-7
Molecular Formula:C₃₀H₂₈Cl₂F₂N₆O₃
Molecular Weight:629.494
Hs Code.:

N-(3-cyano-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Synonyms:N-(3-cyano-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

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Chemical Property of N-(3-cyano-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

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Technology Process of N-(3-cyano-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

There total 18 articles about N-(3-cyano-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₃Cl₃F₂N₄O₃

: 2237-30-1
m-cyanoaniline

: 1360622-16-7
N-(3-cyano-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Guidance literature:: With pyridine; In acetonitrile; at 20 - 55 ℃; for 5.25h;

Reference yield:

: 601-88-7
2,6-dichloronitrobenzene

: 1360622-16-7
N-(3-cyano-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid / 75 °C

2.1: sodium hydroxide; methanol / 4 h / Reflux

3.1: triethylamine / tetrahydrofuran

4.1: hydrogen / Ra-Ni / tetrahydrofuran / 7 h / 2585.81 Torr

5.1: 1,4-dioxane / 10 h / 20 °C / Reflux

6.1: N,N-dimethyl-formamide / 20 °C

6.2: 6 h / 80 °C

7.1: sodium hydroxide; water / ethanol / 96 h

8.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / acetonitrile / 0.5 h / 20 °C

9.1: pyridine / acetonitrile / 5.25 h / 20 - 55 °C

With pyridine; methanol; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sulfuric acid; water; hydrogen; triethylamine; sodium hydroxide; Ra-Ni; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1360624-03-8
N-(3-nitro-2,4-dichloro-benzyl)-2,2,2-trifluoroacetamide

: 1360622-16-7
N-(3-cyano-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide; methanol / 4 h / Reflux

2.1: triethylamine / tetrahydrofuran

3.1: hydrogen / Ra-Ni / tetrahydrofuran / 7 h / 2585.81 Torr

4.1: 1,4-dioxane / 10 h / 20 °C / Reflux

5.1: N,N-dimethyl-formamide / 20 °C

5.2: 6 h / 80 °C

6.1: sodium hydroxide; water / ethanol / 96 h

7.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / acetonitrile / 0.5 h / 20 °C

8.1: pyridine / acetonitrile / 5.25 h / 20 - 55 °C

With pyridine; methanol; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; water; hydrogen; triethylamine; sodium hydroxide; Ra-Ni; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetonitrile;