methyl 1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-chloro-1H-imidazole-5-carboxylate

Base Information

Chemical Name:methyl 1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-chloro-1H-imidazole-5-carboxylate
CAS No.:142096-55-7
Molecular Formula:C₂₂H₂₄ClN₃O₄S
Molecular Weight:461.969
Hs Code.:

Synonyms:methyl 1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-chloro-1H-imidazole-5-carboxylate

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Chemical Property of methyl 1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-chloro-1H-imidazole-5-carboxylate

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Technology Process of methyl 1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-chloro-1H-imidazole-5-carboxylate

There total 8 articles about methyl 1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-chloro-1H-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 142096-54-6
1-((2'-((tert-butylamino)sulfonyl)(1,1'-biphenyl)-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid,methyl ester

: 142096-55-7
methyl 1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-chloro-1H-imidazole-5-carboxylate

Guidance literature:: In methoxybenzene; trifluoroacetic acid;

Reference yield: 70.0%

: 2-Butyl-5-chloro-3-(2'-{[1-dimethylamino-meth-(E)-ylidene]-sulfamoyl}-biphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid methyl ester

: 142096-55-7
methyl 1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-chloro-1H-imidazole-5-carboxylate

Guidance literature:: With hydrogenchloride; In ethanol; for 2h; Heating;
DOI:10.1021/jm00013a013

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 142096-55-7
methyl 1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-chloro-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / aq. Na₂CO₃, triphenylphosphine, palladium acetate / ethanol; toluene / 4 h / Heating

2: 64 percent / N-bromosuccinimide, benzoyl peroxide / chlorobenzene / 1 h / 120 °C

3: 78 percent / K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

4: 77 percent / MnO₂, CH₃COOH, NaCN / 36 h / Ambient temperature

5: 70 percent / conc. HCl / ethanol / 2 h / Heating

With hydrogenchloride; manganese(IV) oxide; N-Bromosuccinimide; Perbenzoic acid; sodium cyanide; palladium diacetate; sodium carbonate; potassium carbonate; acetic acid; triphenylphosphine; In ethanol; N,N-dimethyl-formamide; chlorobenzene; toluene;
DOI:10.1021/jm00013a013