7-pivaloyloxymethyl-3-(2-hydroxy-3-phenoxypropyl)-8-cyclopentylxanthine

Base Information

Chemical Name:7-pivaloyloxymethyl-3-(2-hydroxy-3-phenoxypropyl)-8-cyclopentylxanthine
CAS No.:886440-16-0
Molecular Formula:C₂₅H₃₂N₄O₆
Molecular Weight:484.552
Hs Code.:

Synonyms:7-pivaloyloxymethyl-3-(2-hydroxy-3-phenoxypropyl)-8-cyclopentylxanthine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-pivaloyloxymethyl-3-(2-hydroxy-3-phenoxypropyl)-8-cyclopentylxanthine

Chemical Property:

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Technology Process of 7-pivaloyloxymethyl-3-(2-hydroxy-3-phenoxypropyl)-8-cyclopentylxanthine

There total 7 articles about 7-pivaloyloxymethyl-3-(2-hydroxy-3-phenoxypropyl)-8-cyclopentylxanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 886439-60-7
8-cyclopentyl-3-(2-hydroxy-3-phenoxy-propyl)-3,7-dihydro-purine-2,6-dione

: 18997-19-8
Chloromethyl pivalate

: 886440-16-0
7-pivaloyloxymethyl-3-(2-hydroxy-3-phenoxypropyl)-8-cyclopentylxanthine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 - 70 ℃; for 6h;
DOI:10.1016/j.bmc.2005.11.050

Reference yield:

: 32968-43-7
5-(phenoxymethyl)-2-amino-2-oxazoline

: 886440-16-0
7-pivaloyloxymethyl-3-(2-hydroxy-3-phenoxypropyl)-8-cyclopentylxanthine

Guidance literature:: Multi-step reaction with 7 steps

1: 43 percent / sodium; methanol / 5 h / Heating

2: 83 percent / sodium nitrite; acetic acid / H₂O / 1.5 h / 20 - 60 °C

3: 83 percent / sodium; ethanol / 8 h / Heating

4: 68 percent / sodium dithionite / H₂O / 0.5 h / Heating

5: 86 percent / pyridine

6: 55 percent / sodium hydroxide / H₂O; ethanol / 1.5 h / Heating

7: 61 percent / potassium carbonate / dimethylformamide / 6 h / 60 - 70 °C

With pyridine; methanol; sodium hydroxide; sodium dithionite; ethanol; sodium; potassium carbonate; acetic acid; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide; 1: Pinner reaction;
DOI:10.1016/j.bmc.2005.11.050

Reference yield:

: 886439-93-6
5-amino-2-phenoxymethyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one

: 886440-16-0
7-pivaloyloxymethyl-3-(2-hydroxy-3-phenoxypropyl)-8-cyclopentylxanthine

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / sodium nitrite; acetic acid / H₂O / 1.5 h / 20 - 60 °C

2: 83 percent / sodium; ethanol / 8 h / Heating

3: 68 percent / sodium dithionite / H₂O / 0.5 h / Heating

4: 86 percent / pyridine

5: 55 percent / sodium hydroxide / H₂O; ethanol / 1.5 h / Heating

6: 61 percent / potassium carbonate / dimethylformamide / 6 h / 60 - 70 °C

With pyridine; sodium hydroxide; sodium dithionite; ethanol; sodium; potassium carbonate; acetic acid; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.050