methyl (2S,4R)-2-(2-hydroxyphenyl)-3-<4-(methoxycarbonyl)butyryl>-4-thiazolidinecarboxylate

Base Information

• Chemical Name: methyl (2S,4R)-2-(2-hydroxyphenyl)-3-<4-(methoxycarbonyl)butyryl>-4-thiazolidinecarboxylate
• CAS No.: 102293-08-3
• Molecular Formula: C₁₇H₂₁NO₆S
• Molecular Weight: 367.423
• Mol file: 102293-08-3.mol

Synonyms:methyl (2S,4R)-2-(2-hydroxyphenyl)-3-<4-(methoxycarbonyl)butyryl>-4-thiazolidinecarboxylate

Chemical Property of methyl (2S,4R)-2-(2-hydroxyphenyl)-3-<4-(methoxycarbonyl)butyryl>-4-thiazolidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2S,4R)-2-(2-hydroxyphenyl)-3-<4-(methoxycarbonyl)butyryl>-4-thiazolidinecarboxylate

There total 1 articles about methyl (2S,4R)-2-(2-hydroxyphenyl)-3-<4-(methoxycarbonyl)butyryl>-4-thiazolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + glutaric anhydride, (108-55-4) + (2RS,4R)-2-(2-hydroxy-phenyl)-thiazolidine-4-carboxylic acid (201942-90-7) → methyl (2R,4R)-2-(2-hydroxyphenyl)-3-<4-(methoxycarbonyl)butyryl>-4-thiazolidinecarboxylate (102293-07-2) + methyl (2S,4R)-2-(2-hydroxyphenyl)-3-<4-(methoxycarbonyl)butyryl>-4-thiazolidinecarboxylate (102293-08-3)

Guidance literature:

With pyridine; sulfuric acid; Yield given. Multistep reaction; 1.) 4 h, room temperature; 2.) ether/AcOEt;

DOI:10.1248/cpb.33.5341

Reference yield: 88.0%

methyl (2S,4R)-2-(2-hydroxyphenyl)-3-<4-(methoxycarbonyl)butyryl>-4-thiazolidinecarboxylate (102293-08-3) → (2S,4R)-3-(4-carboxybutyryl)-2-(2-hydroxyphenyl)-4-thiazolidinecarboxylic acid (102293-06-1)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In water; for 2h;

DOI:10.1248/cpb.33.5341

upstream raw materials:

diazomethane

glutaric anhydride,

(2RS,4R)-2-(2-hydroxy-phenyl)-thiazolidine-4-carboxylic acid

Downstream raw materials:

(2S,4R)-3-(4-carboxybutyryl)-2-(2-hydroxyphenyl)-4-thiazolidinecarboxylic acid