[3-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-5-chlorophenyl]morpholinomethanone

Base Information

Chemical Name:[3-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-5-chlorophenyl]morpholinomethanone
CAS No.:1617499-02-1
Molecular Formula:C₂₁H₂₃ClN₆O₂
Molecular Weight:426.906
Hs Code.:

Synonyms:[3-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-5-chlorophenyl]morpholinomethanone

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Chemical Property of [3-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-5-chlorophenyl]morpholinomethanone

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Technology Process of [3-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-5-chlorophenyl]morpholinomethanone

There total 2 articles about [3-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-5-chlorophenyl]morpholinomethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 957120-55-7
(3-chloro-5-(morpholine-4-carbonyl)phenyl)boronic acid

: 1617499-16-7
5-bromo-3-(1-isopropyl-1H-[1,2,3]triazol-4-yl)-pyridin-2-ylamine

: 1617499-02-1
[3-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-5-chlorophenyl]morpholinomethanone

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 120 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1210838-82-6
5-bromo-3-ethynyl-pyridin-2-ylamine

: 1617499-02-1
[3-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-5-chlorophenyl]morpholinomethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium azide / water; tert-butyl alcohol / 2 h / 80 °C

1.2: 16 h / 80 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium azide; caesium carbonate; In 1,4-dioxane; water; tert-butyl alcohol;

Reference yield: 20.2%

: 1617499-02-1
[3-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-5-chlorophenyl]morpholinomethanone

: 1617499-03-2
5-[3-chloro-5-(morpholinomethyl)phenyl]-3-(1-isopropyltriazol-4-yl)pyridin-2-amine

Guidance literature:: [3-[6-amino-5-(1-isopropyltriazol-4-yl)-3-pyridyl]-5-chlorophenyl]morpholinomethanone; With boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 ℃; for 0.5h;

With sodium tetrahydroborate; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

With methanol; In tetrahydrofuran; at 70 ℃; for 2h;