2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-1-yl)methyl-4-fluorobenzonitrile

Base Information

Chemical Name:2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-1-yl)methyl-4-fluorobenzonitrile
CAS No.:1417715-74-2
Molecular Formula:C₁₆H₁₀BrFN₆O₂
Molecular Weight:417.197
Hs Code.:

Synonyms:2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-1-yl)methyl-4-fluorobenzonitrile

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Chemical Property of 2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-1-yl)methyl-4-fluorobenzonitrile

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Technology Process of 2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-1-yl)methyl-4-fluorobenzonitrile

There total 10 articles about 2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-1-yl)methyl-4-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 2-bromo-5-methyl-1,5-dihydro-9H-imidazo[1,2-a]purine-6,9(7H)-dione TFA salt

: 421552-12-7
2-(bromomethyl)-4-fluorobenzonitrile

: 1417715-74-2
2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-1-yl)methyl-4-fluorobenzonitrile

: 1417715-75-3
2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-3-yl)methyl-4-fluorobenzonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/acsmedchemlett.6b00027

Reference yield:

: C₈H₆BrN₅O₂*C₂HF₃O₂

: 421552-12-7
2-(bromomethyl)-4-fluorobenzonitrile

: 1417715-74-2
2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-1-yl)methyl-4-fluorobenzonitrile

: 1417715-75-3
2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-3-yl)methyl-4-fluorobenzonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 115204-74-5
2,6-dichloro-9-(4-methoxyphenylmethyl)-9H-purine

: 1417715-74-2
2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-1-yl)methyl-4-fluorobenzonitrile

: 1417715-75-3
2-(2-bromo-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-3-yl)methyl-4-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / 2 h / Reflux

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 50 °C

3: 1,4-dioxane / 20 h / 20 °C

4: hydrogenchloride / methanol / 3 h / Reflux

5: 5 h / 100 °C / Microwave irradiation

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.6b00027