Technology Process of (S)-3-[(5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carbonyl)amino]-(R)-2-hydroxy-4-phenylbutyric acid
There total 4 articles about (S)-3-[(5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carbonyl)amino]-(R)-2-hydroxy-4-phenylbutyric acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide; water;
In
methanol;
at 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1,4-diaza-bicyclo[2.2.2]octane / palladium diacetate / DMF (N,N-dimethyl-formamide) / 21 h / 20 - 107 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 72 h / 20 °C
3: sodium hydroxide; water / methanol / 24 h / 20 °C
With
1,4-diaza-bicyclo[2.2.2]octane; sodium hydroxide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
palladium diacetate;
In
methanol; DMF (N,N-dimethyl-formamide);
1: Heck Reaction;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium ethoxide / diethyl ether; ethanol / 0.5 h / 20 °C
1.2: 15 h / 20 °C
2.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 2 h / Heating / reflux
3.1: sodium hydroxide; water / ethanol / 2 h / Heating / reflux
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 72 h / 20 °C
5.1: sodium hydroxide; water / methanol / 24 h / 20 °C
With
sodium hydroxide; potassium ethoxide; water; iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); diethyl ether; ethanol; water;