Technology Process of (2'S,4'S)-7-(4'-acetamido-2'-methylpyrrolidinyl)-1-(2,4-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxoquinoline-3-carboxylic acid ethyl ester
There total 13 articles about (2'S,4'S)-7-(4'-acetamido-2'-methylpyrrolidinyl)-1-(2,4-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxoquinoline-3-carboxylic acid ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 99 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature
2: 93 percent / lithium borohydride / tetrahydrofuran / 16 h
3: 94 percent / triethylamine / CH2Cl2 / 15 h
4: lithium triethylborohydride / tetrahydrofuran / 2 h
5: tetra-n-butylammonium fluoride / tetrahydrofuran / 2.5 h
6: 16.1 g / triethylamine / CH2Cl2 / 14 h
7: 43 percent / tetra-n-butylammonium azide / acetonitrile / 3 h / 65 °C
8: hydrogen / 10percent palladium on carbon / methanol / 1 h / 3040 Torr
9: triethylamine / pyridine / 19 h / Ambient temperature
10: trifluoroacetic acid / 0.25 h
11: triethylamine / pyridine / 48 h / 40 °C
With
1H-imidazole; lithium borohydride; tetrabutyl ammonium fluoride; hydrogen; tetrabutylammoniun azide; lithium triethylborohydride; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00403a020
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 90 percent / triethylamine / CH2Cl2 / 12 h
2: 99 percent / imidazole / dimethylformamide / 1.5 h / Ambient temperature
3: 93 percent / lithium borohydride / tetrahydrofuran / 16 h
4: 94 percent / triethylamine / CH2Cl2 / 15 h
5: lithium triethylborohydride / tetrahydrofuran / 2 h
6: tetra-n-butylammonium fluoride / tetrahydrofuran / 2.5 h
7: 16.1 g / triethylamine / CH2Cl2 / 14 h
8: 43 percent / tetra-n-butylammonium azide / acetonitrile / 3 h / 65 °C
9: hydrogen / 10percent palladium on carbon / methanol / 1 h / 3040 Torr
10: triethylamine / pyridine / 19 h / Ambient temperature
11: trifluoroacetic acid / 0.25 h
12: triethylamine / pyridine / 48 h / 40 °C
With
1H-imidazole; lithium borohydride; tetrabutyl ammonium fluoride; hydrogen; tetrabutylammoniun azide; lithium triethylborohydride; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00403a020
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogen / 10percent palladium on carbon / methanol / 1 h / 3040 Torr
2: triethylamine / pyridine / 19 h / Ambient temperature
3: trifluoroacetic acid / 0.25 h
4: triethylamine / pyridine / 48 h / 40 °C
With
hydrogen; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
pyridine; methanol;
DOI:10.1021/jm00403a020
