Lysogb3

Base Information

• Chemical Name: Lysogb3
• CAS No.: 126550-86-5
• Molecular Formula: C36H67 N O17
• Molecular Weight: 785.91
• Nikkaji Number: J3.542.079G
• Mol file: 126550-86-5.mol

Synonyms:Gb3 lysosphingolipid;globotriaosyl lysosphingolipid;lyso-Gb3;lyso-GL-3;lyso-globotriaosylsphingosine;lysoGb3

Chemical Property of Lysogb3

Chemical Property:

• Boiling Point: 1005.8±65.0 °C(Predicted)
• PKA: 11.74±0.45(Predicted)
• Flash Point: 562.1oC
• PSA: 303.93000
• Density: 1.37±0.1 g/cm3(Predicted)
• LogP: -1.90290
• Storage Temp.: −20°C
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 12
• Hydrogen Bond Acceptor Count: 18
• Rotatable Bond Count: 24
• Exact Mass: 785.44089967
• Heavy Atom Count: 54
• Complexity: 1030

Purity/Quality:

97% ^*data from raw suppliers

Globotriaosylsphingosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCCCCCCCCCCC=CC(C(COC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)OC3C(C(C(C(O3)CO)O)O)O)O)O)O)O)N)O
• Isomeric SMILES: CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O[C@@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)O)O)O)O)O)N)O
• Uses: Globotriaosylceramid?e Sphingosine tert-Butyldimethylsilyl is a Fabry disease biomarker.

Technology Process of Lysogb3

There total 10 articles about Lysogb3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(2R,3R,4S,5R,6R)-2-[(2R,3R,4R,5R,6S)-6-((2R,3S,4R,5R,6R)-6-Fluoro-4,5-dihydroxy-2-hydroxymethyl-tetrahydro-pyran-3-yloxy)-4,5-dihydroxy-2-hydroxymethyl-tetrahydro-pyran-3-yloxy]-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol + (2S,3R,4E)-2-amino-4-octadecene-1,3-diol (123-78-4) → globotriaosylsphingosine (126550-86-5)

Guidance literature:

With endoglycoceramidase II E₃₅₁S mutant glycosynthase; Triton X-100; In acetate buffer; at 20 ℃; pH=5.0; Enzymatic reaction;

DOI:10.1021/ja058469n

Reference yield:

C76H119NO27 → globotriaosylsphingosine (126550-86-5)

Guidance literature:

With sodium methylate; In methanol; at 60 ℃; for 24h; Yield given;

DOI:10.1016/0008-6215(90)84079-A

Reference yield:

(2S,3R,4E)-2-(N-tert-butyloxycarbonylamino)-3-hydroxyoctadec-4-en-1-yl α-galactopyranosyl-(1→4)-β-galactopyranosyl-(1→4)-β-glucopyranoside → globotriaosylsphingosine (126550-86-5)

Guidance literature:

With zinc dibromide; In methanol; at 20 ℃;

DOI:10.1021/acs.orglett.0c02847

upstream raw materials:

(2S,3R,4E)-2-amino-4-octadecene-1,3-diol

tert-butyl ((2S,3R)-1,3-dihydroxypent-4-en-2-yl)carbamate

2,3,6,2',3',4',6'-hepta-O-acetyl-α-D-lactosyl trichloroacetimidate

Downstream raw materials:

(2S,3R,4E)-1-O-<(α-D-galactopyranosyl)-(1->4)-(β-D-galactopyranosyl)-(1->4)-β-D-glucopyranosyloxy>-2-(hexadecanoylamino)-4-octadecen-3-ol

(2S,3R,4E)-2-hexadecanamido-3-hydroxyoctadec-4-en-1-yl α-galactopyranosyl-(1→4)-β-galactopyranosyl-(1→4)-β-glucopyranoside

globotriaosyl-E-ceramide

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