(S)-N-[(2R,R_S)-1-phenyl-2-p-tolylsulfinylethyl]-p-toluenesulfinamide

Base Information

• Chemical Name: (S)-N-[(2R,R_S)-1-phenyl-2-p-tolylsulfinylethyl]-p-toluenesulfinamide
• CAS No.: 280128-26-9
• Molecular Formula: C₂₂H₂₃NO₂S₂
• Molecular Weight: 397.562
• Mol file: 280128-26-9.mol

Synonyms:(S)-N-[(2R,R_S)-1-phenyl-2-p-tolylsulfinylethyl]-p-toluenesulfinamide

Chemical Property of (S)-N-[(2R,R_S)-1-phenyl-2-p-tolylsulfinylethyl]-p-toluenesulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-[(2R,R_S)-1-phenyl-2-p-tolylsulfinylethyl]-p-toluenesulfinamide

There total 2 articles about (S)-N-[(2R,R_S)-1-phenyl-2-p-tolylsulfinylethyl]-p-toluenesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-methyl p-tolyl sulfoxide (1519-39-7) + (S,E)-N-benzylidene-4-methylbenzenesulfinamide (350479-90-2) → (S)-N-[(2R,RS)-1-phenyl-2-p-tolylsulfinylethyl]-p-toluenesulfinamide (280128-26-9)

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h;

DOI:10.1021/jo9903858

Reference yield:

(R)-methyl p-tolyl sulfoxide (1519-39-7) + (S,E)-N-benzylidene-4-methylbenzenesulfinamide (350479-90-2) → (S)-N-[(2R,RS)-1-phenyl-2-p-tolylsulfinylethyl]-p-toluenesulfinamide (280128-26-9) + 4-Methyl-benzenesulfinic acid [(S)-1-phenyl-2-((R)-toluene-4-sulfinyl)-ethyl]-amide

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at 0 ℃; Title compound not separated from byproducts.;

DOI:10.1021/jo9903858

Reference yield: 95.0%

(S)-N-[(2R,RS)-1-phenyl-2-p-tolylsulfinylethyl]-p-toluenesulfinamide (280128-26-9) → (1R,RS)-1-phenyl-2-p-tolylsulfinylethylamine (280128-39-4)

Guidance literature:

With trifluoroacetic acid; In methanol; at 20 ℃; for 15h;

DOI:10.1021/jo9903858

upstream raw materials:

(R)-methyl p-tolyl sulfoxide

(S,E)-N-benzylidene-4-methylbenzenesulfinamide

Downstream raw materials:

(1R,R_S)-1-phenyl-2-p-tolylsulfinylethylamine

D-2-phenylglycinol

(R)-N-(tert-butoxycarbonyl)phenylglycinol

tert-butyl N-[(1R,R_S)-1-phenyl-2-p-tolylsulfinylethyl]carbamate