N-[2-(3-hydroxybenzyl)-4-methyl-1,3-thiazol-5-yl]-1-methyl-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-[2-(3-hydroxybenzyl)-4-methyl-1,3-thiazol-5-yl]-1-methyl-1H-pyrazole-5-carboxamide
CAS No.:1318757-14-0
Molecular Formula:C₁₆H₁₆N₄O₂S
Molecular Weight:328.395
Hs Code.:

Synonyms:N-[2-(3-hydroxybenzyl)-4-methyl-1,3-thiazol-5-yl]-1-methyl-1H-pyrazole-5-carboxamide

Suppliers and Price of N-[2-(3-hydroxybenzyl)-4-methyl-1,3-thiazol-5-yl]-1-methyl-1H-pyrazole-5-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(3-hydroxybenzyl)-4-methyl-1,3-thiazol-5-yl]-1-methyl-1H-pyrazole-5-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[2-(3-hydroxybenzyl)-4-methyl-1,3-thiazol-5-yl]-1-methyl-1H-pyrazole-5-carboxamide

There total 6 articles about N-[2-(3-hydroxybenzyl)-4-methyl-1,3-thiazol-5-yl]-1-methyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1318757-08-2
N-[2-(3-methoxybenzyl)-4-methyl-1,3-thiazol-5-yl]-1-methyl-1H-pyrazole-5-carboxamide

: 1318757-14-0
N-[2-(3-hydroxybenzyl)-4-methyl-1,3-thiazol-5-yl]-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: With boron tribromide; In hexane; toluene; at 20 - 50 ℃; for 6h;

Reference yield:

: 19924-43-7
3-methoxyphenylacetonitrile

: 1318757-14-0
N-[2-(3-hydroxybenzyl)-4-methyl-1,3-thiazol-5-yl]-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / 1,4-dioxane / 18 h / 20 °C

2.1: pyridine / ethanol / 18 h / 60 °C

3.1: sodium hydroxide; water / ethanol / 3 h / 20 °C

3.2: Cooling with ice

4.1: triethylamine; diphenyl phosphoryl azide / 3 h / 95 °C

5.1: hydrogenchloride / ethanol; water / 1.5 h / 50 °C

5.2: 0 °C / pH 10 - 11

5.3: 2 h / 60 °C

6.1: boron tribromide / toluene; hexane / 6 h / 20 - 50 °C

With pyridine; hydrogenchloride; diphenyl phosphoryl azide; water; boron tribromide; O,O-Diethyl hydrogen phosphorodithioate; triethylamine; sodium hydroxide; In 1,4-dioxane; ethanol; hexane; water; toluene;

Reference yield:

: 1318758-22-3
ethyl 2-(3-methoxybenzyl)-4-methyl-1,3-thiazole-5-carboxylate

: 1318757-14-0
N-[2-(3-hydroxybenzyl)-4-methyl-1,3-thiazol-5-yl]-1-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / ethanol / 3 h / 20 °C

1.2: Cooling with ice

2.1: triethylamine; diphenyl phosphoryl azide / 3 h / 95 °C

3.1: hydrogenchloride / ethanol; water / 1.5 h / 50 °C

3.2: 0 °C / pH 10 - 11

3.3: 2 h / 60 °C

4.1: boron tribromide / toluene; hexane / 6 h / 20 - 50 °C

With hydrogenchloride; diphenyl phosphoryl azide; water; boron tribromide; triethylamine; sodium hydroxide; In ethanol; hexane; water; toluene;