2-tert-butoxy-2-(4-(4-chlorophenyl)-1-(2-hydroxyethyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Base Information

Chemical Name:2-tert-butoxy-2-(4-(4-chlorophenyl)-1-(2-hydroxyethyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid
CAS No.:1436854-94-2
Molecular Formula:C₂₄H₂₉ClN₂O₄
Molecular Weight:444.958
Hs Code.:

Synonyms:2-tert-butoxy-2-(4-(4-chlorophenyl)-1-(2-hydroxyethyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

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Chemical Property of 2-tert-butoxy-2-(4-(4-chlorophenyl)-1-(2-hydroxyethyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

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Technology Process of 2-tert-butoxy-2-(4-(4-chlorophenyl)-1-(2-hydroxyethyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

There total 16 articles about 2-tert-butoxy-2-(4-(4-chlorophenyl)-1-(2-hydroxyethyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: C₂₅H₃₁ClN₂O₄

: 1436854-94-2
2-tert-butoxy-2-(4-(4-chlorophenyl)-1-(2-hydroxyethyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Guidance literature:: With methanol; sodium hydroxide; In tetrahydrofuran; at 30 ℃; for 18h;

Reference yield:

: 1436855-92-3
methyl 2-tert-butoxy-2-(1-(2-((tert-butyldimethylsilyl)oxy)ethyl)-4-(4-chlorophenyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate

: 1436854-94-2
2-tert-butoxy-2-(4-(4-chlorophenyl)-1-(2-hydroxyethyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

2: sodium hydroxide; methanol / tetrahydrofuran / 18 h / 30 °C

With methanol; tetrabutyl ammonium fluoride; acetic acid; sodium hydroxide; In tetrahydrofuran;

Reference yield:

: 1436855-52-5
4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridine-5-carboaldehyde

: 1436854-94-2
2-tert-butoxy-2-(4-(4-chlorophenyl)-1-(2-hydroxyethyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

2: hydrogenchloride / water / 18 h / 100 °C

3: sulfuric acid / 18 h / Reflux

4: perchloric acid / dichloromethane; ethyl acetate / 4 h / 0 - 20 °C

5: tetrabutylammomium bromide; potassium hydroxide / dichloromethane / 4 h / 30 °C

6: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

7: sodium hydroxide; methanol / tetrahydrofuran / 18 h / 30 °C

With hydrogenchloride; methanol; perchloric acid; sulfuric acid; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; acetic acid; potassium hydroxide; sodium hydroxide; zinc(II) iodide; In tetrahydrofuran; dichloromethane; water; ethyl acetate;