(3S,5S)-5-benzyl-3-(4-benzyl-5-(diethylamino)oxazol-2-yl)-3-methylmorpholin-2-one

Base Information

• Chemical Name: (3S,5S)-5-benzyl-3-(4-benzyl-5-(diethylamino)oxazol-2-yl)-3-methylmorpholin-2-one
• CAS No.: 1407675-00-6
• Molecular Formula: C₂₆H₃₁N₃O₃
• Molecular Weight: 433.55

Synonyms:(3S,5S)-5-benzyl-3-(4-benzyl-5-(diethylamino)oxazol-2-yl)-3-methylmorpholin-2-one

Chemical Property of (3S,5S)-5-benzyl-3-(4-benzyl-5-(diethylamino)oxazol-2-yl)-3-methylmorpholin-2-one

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Technology Process of (3S,5S)-5-benzyl-3-(4-benzyl-5-(diethylamino)oxazol-2-yl)-3-methylmorpholin-2-one

There total 2 articles about (3S,5S)-5-benzyl-3-(4-benzyl-5-(diethylamino)oxazol-2-yl)-3-methylmorpholin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C12H13NO2 (1355545-47-9) + N,N-diethyl-α-isocyano-β-phenylpropionamide (500555-97-5) → (3S,5S)-5-benzyl-3-(4-benzyl-5-(diethylamino)oxazol-2-yl)-3-methylmorpholin-2-one (1407675-00-6)

Guidance literature:

With phenylphosphinic acid; In 2,2,2-trifluoroethanol; at 20 ℃; for 2h; stereoselective reaction;

DOI:10.1055/s-0032-1316549

Reference yield: 78.0%

C14H18N2O (1027967-54-9) + C12H13NO2 (1355545-47-9) → (3S,5S)-5-benzyl-3-(4-benzyl-5-(diethylamino)oxazol-2-yl)-3-methylmorpholin-2-one (1407675-00-6)

Guidance literature:

With phenylphosphinic acid; In 2,2,2-trifluoroethanol; at 20 ℃; for 2h; diastereoselective reaction;

DOI:10.1021/jo4000702

Reference yield: 72.0%

maleic anhydride (108-31-6) + (3S,5S)-5-benzyl-3-(4-benzyl-5-(diethylamino)oxazol-2-yl)-3-methylmorpholin-2-one (1407675-00-6) → (7S,10aS)-2,7-dibenzyl-3-(diethylamino)-10a-methyl-7,8-dihydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-5,10(10aH)-dione (1426332-99-1)

Guidance literature:

In toluene; at 110 ℃; for 5h; Molecular sieve;

DOI:10.1021/jo4000702

upstream raw materials:

C₁₂H₁₃NO₂

N,N-diethyl-α-isocyano-β-phenylpropionamide

C₁₄H₁₈N₂O

Downstream raw materials:

(7S,10aS)-2,7-dibenzyl-3-(diethylamino)-10a-methyl-7,8-dihydro-5H-pyrido[2',3':3,4]pyrrolo[2,1-c][1,4]oxazine-5,10(10aH)-dione

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