(R)-2-[(methoxycarbonyl)amino]-2-(4-methoxyphenyl)-1-ethanol

Base Information

• Chemical Name: (R)-2-[(methoxycarbonyl)amino]-2-(4-methoxyphenyl)-1-ethanol
• CAS No.: 1268345-15-8
• Molecular Formula: C₁₁H₁₅NO₄
• Molecular Weight: 225.244
• Mol file: 1268345-15-8.mol

Synonyms:(R)-2-[(methoxycarbonyl)amino]-2-(4-methoxyphenyl)-1-ethanol

Chemical Property of (R)-2-[(methoxycarbonyl)amino]-2-(4-methoxyphenyl)-1-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-[(methoxycarbonyl)amino]-2-(4-methoxyphenyl)-1-ethanol

There total 3 articles about (R)-2-[(methoxycarbonyl)amino]-2-(4-methoxyphenyl)-1-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl (R)-2-[(methoxycarbonyl)amino]-2-(4-methoxyphenyl) acetate (1268345-14-7) → (R)-2-[(methoxycarbonyl)amino]-2-(4-methoxyphenyl)-1-ethanol (1268345-15-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -20 - 0 ℃; for 4h; Inert atmosphere;

DOI:10.1002/chem.201002063

Reference yield:

(R)-2-(4-hydroxyphenyl)-2-[(methoxycarbonyl)amino]acetic acid (77568-43-5) → (R)-2-[(methoxycarbonyl)amino]-2-(4-methoxyphenyl)-1-ethanol (1268345-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -20 - 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.1002/chem.201002063

Reference yield:

D-4-hydroxyphenylglycine (22818-40-2) → (R)-2-[(methoxycarbonyl)amino]-2-(4-methoxyphenyl)-1-ethanol (1268345-15-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

2: potassium carbonate / acetone / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -20 - 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; water; acetone;

DOI:10.1002/chem.201002063

upstream raw materials:

(R)-2-(4-hydroxyphenyl)-2-[(methoxycarbonyl)amino]acetic acid

methyl (R)-2-[(methoxycarbonyl)amino]-2-(4-methoxyphenyl) acetate

D-4-hydroxyphenylglycine

Downstream raw materials:

1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-1H-pyrrol-2(5H)-one

1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-5-D-1H-pyrrol-2(5H)-one

1-[(R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-5-methyl-1H-pyrrol-2(5H)-one

1-[(S)-2-hydroxy-1-(4-methoxyphenyl)ethyl]-4-methoxy-5-methyl-1H-pyrrol-2(5H)-one