N-(3-bromo-phenyl)-N-(3-hydroxy-8-methoxy-2,2-dimethyl-4-piperidin-1-yl-chroman-7-ylmethyl)-benzamide

Base Information

Chemical Name:N-(3-bromo-phenyl)-N-(3-hydroxy-8-methoxy-2,2-dimethyl-4-piperidin-1-yl-chroman-7-ylmethyl)-benzamide
CAS No.:1055899-48-3
Molecular Formula:C₃₁H₃₅BrN₂O₄
Molecular Weight:579.534
Hs Code.:

<i>N</i>-(3-bromo-phenyl)-<i>N</i>-(3-hydroxy-8-methoxy-2,2-dimethyl-4-piperidin-1-yl-chroman-7-ylmethyl)-benzamide

Synonyms:N-(3-bromo-phenyl)-N-(3-hydroxy-8-methoxy-2,2-dimethyl-4-piperidin-1-yl-chroman-7-ylmethyl)-benzamide

Suppliers and Price of N-(3-bromo-phenyl)-N-(3-hydroxy-8-methoxy-2,2-dimethyl-4-piperidin-1-yl-chroman-7-ylmethyl)-benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-bromo-phenyl)-N-(3-hydroxy-8-methoxy-2,2-dimethyl-4-piperidin-1-yl-chroman-7-ylmethyl)-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-bromo-phenyl)-N-(3-hydroxy-8-methoxy-2,2-dimethyl-4-piperidin-1-yl-chroman-7-ylmethyl)-benzamide

There total 8 articles about N-(3-bromo-phenyl)-N-(3-hydroxy-8-methoxy-2,2-dimethyl-4-piperidin-1-yl-chroman-7-ylmethyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 110-89-4
piperidine

: N-(3-bromo-phenyl)-N-(4-methoxy-2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalen-5-ylmethyl)-benzamide

: 1055899-48-3
N-(3-bromo-phenyl)-N-(3-hydroxy-8-methoxy-2,2-dimethyl-4-piperidin-1-yl-chroman-7-ylmethyl)-benzamide

Guidance literature:: In dichloromethane; at 25 ℃; for 48h;
DOI:10.1039/b300525a

Reference yield:

: 698362-69-5
3-(1,1-dimethyl-prop-2-ynyloxy)-2-methoxy-benzaldehyde

: 1055899-48-3
N-(3-bromo-phenyl)-N-(3-hydroxy-8-methoxy-2,2-dimethyl-4-piperidin-1-yl-chroman-7-ylmethyl)-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / N,N-diethylaniline / 0.5 h / 190 °C

2: tetrahydrofuran / 4 h / 70 °C

3: NaCNBH₃ / methanol / 4 h / 70 °C

4: 95 percent / Et₃N; 4-DMAP / CH₂Cl₂ / 24 h / 25 °C

5: 100 percent / dimethyldioxirane / acetone / 1 h / 0 °C

6: 65 percent / CH₂Cl₂ / 48 h / 25 °C

With dmap; 3,3-dimethyldioxirane; sodium cyanoborohydride; triethylamine; N,N-diethylaniline; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1039/b300525a

Reference yield:

: 24677-78-9
2,3-dihydroxybenzaldehyde

: 1055899-48-3
N-(3-bromo-phenyl)-N-(3-hydroxy-8-methoxy-2,2-dimethyl-4-piperidin-1-yl-chroman-7-ylmethyl)-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: NaH

2: 75 percent / DBU; trifluoroacetic anhydride; CuCl₂ / acetonitrile / 12 h / 0 - 25 °C

3: 90 percent / N,N-diethylaniline / 0.5 h / 190 °C

4: tetrahydrofuran / 4 h / 70 °C

5: NaCNBH₃ / methanol / 4 h / 70 °C

6: 95 percent / Et₃N; 4-DMAP / CH₂Cl₂ / 24 h / 25 °C

7: 100 percent / dimethyldioxirane / acetone / 1 h / 0 °C

8: 65 percent / CH₂Cl₂ / 48 h / 25 °C

With dmap; 3,3-dimethyldioxirane; sodium hydride; sodium cyanoborohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-diethylaniline; trifluoroacetic anhydride; copper dichloride; In tetrahydrofuran; methanol; dichloromethane; acetone; acetonitrile;
DOI:10.1039/b300525a