3-(2,5-dimethoxy-phenyl)-5-(4-methoxy-3-nitro-phenyl)-1H-pyrazole

Base Information

• Chemical Name: 3-(2,5-dimethoxy-phenyl)-5-(4-methoxy-3-nitro-phenyl)-1H-pyrazole
• CAS No.: 866261-53-2
• Molecular Formula: C₁₈H₁₇N₃O₅
• Molecular Weight: 355.35
• Mol file: 866261-53-2.mol

Synonyms:3-(2,5-dimethoxy-phenyl)-5-(4-methoxy-3-nitro-phenyl)-1H-pyrazole

Chemical Property of 3-(2,5-dimethoxy-phenyl)-5-(4-methoxy-3-nitro-phenyl)-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(2,5-dimethoxy-phenyl)-5-(4-methoxy-3-nitro-phenyl)-1H-pyrazole

There total 2 articles about 3-(2,5-dimethoxy-phenyl)-5-(4-methoxy-3-nitro-phenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2,3-epoxy-1-(2',5'-dimethoxyphenyl)-3-(4''-methoxy-3''-nitrophenyl)propanone → 3-(2,5-dimethoxy-phenyl)-5-(4-methoxy-3-nitro-phenyl)-1H-pyrazole (866261-53-2)

Guidance literature:

With toluene-4-sulfonic acid; hydrazine hydrate; In xylene; for 3h; Heating;

DOI:10.1016/j.bmc.2005.06.028

Reference yield:

(E)-1-(2,5-Dimethoxy-phenyl)-3-(4-methoxy-3-nitro-phenyl)-propenone → 3-(2,5-dimethoxy-phenyl)-5-(4-methoxy-3-nitro-phenyl)-1H-pyrazole (866261-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / H₂O₂; K₂CO₃ / methanol; H₂O / 3 h / 20 °C

2: 83 percent / hydrazine hydrate; p-toluenesulfonic acid monohydrate / xylene / 3 h / Heating

With dihydrogen peroxide; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; In methanol; water; xylene;

DOI:10.1016/j.bmc.2005.06.028

Reference yield: 94.0%

3-(2,5-dimethoxy-phenyl)-5-(4-methoxy-3-nitro-phenyl)-1H-pyrazole (866261-53-2) → 5-[5-(2,5-dimethoxy-phenyl)-2H-pyrazol-3-yl]-2-methoxy-phenylamine

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃; for 4h; ambient pressure;

DOI:10.1016/j.bmc.2005.06.028