(S)-2-((S)-2-methoxymethylpyrrolidin-1-yl)-3-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-isoquinolin-1-one

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Chemical Name:(S)-2-((S)-2-methoxymethylpyrrolidin-1-yl)-3-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-isoquinolin-1-one
CAS No.:1393378-84-1
Molecular Formula:C₂₄H₃₀N₂O₅
Molecular Weight:426.513
Hs Code.:

Synonyms:(S)-2-((S)-2-methoxymethylpyrrolidin-1-yl)-3-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-isoquinolin-1-one

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Chemical Property of (S)-2-((S)-2-methoxymethylpyrrolidin-1-yl)-3-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-isoquinolin-1-one

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Technology Process of (S)-2-((S)-2-methoxymethylpyrrolidin-1-yl)-3-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-isoquinolin-1-one

There total 3 articles about (S)-2-((S)-2-methoxymethylpyrrolidin-1-yl)-3-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-isoquinolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1393378-78-3
N-((S)-2-methoxymethylpyrrolidin-1-yl)-N-[1-(3,4,5-trimethoxyphenyl)vinyl]benzamide

: 1393378-84-1
(S)-2-((S)-2-methoxymethylpyrrolidin-1-yl)-3-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: In methanol; for 4h; optical yield given as %de; diastereoselective reaction; Irradiation; Inert atmosphere;
DOI:10.1016/j.tet.2012.06.037

Reference yield:

: 1393378-74-9
N-acetyl-N-((S)-2-methoxymethylpyrrolidin-1-yl)benzamide

: 1393378-84-1
(S)-2-((S)-2-methoxymethylpyrrolidin-1-yl)-3-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 2 h / Inert atmosphere; Reflux

3: methanol / 4 h / Irradiation; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hexamethylsilazane; sodium carbonate; In tetrahydrofuran; methanol; water; toluene; 2: Suzuki-Miyaura cross-coupling;
DOI:10.1016/j.tet.2012.06.037

Reference yield:

: C₂₇H₂₉N₂O₆P

: 1393378-84-1
(S)-2-((S)-2-methoxymethylpyrrolidin-1-yl)-3-(3,4,5-trimethoxyphenyl)-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 2 h / Inert atmosphere; Reflux

2: methanol / 4 h / Irradiation; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; methanol; water; 1: Suzuki-Miyaura cross-coupling;
DOI:10.1016/j.tet.2012.06.037