tert-butyl (3R)-3-[{[4-(2-{[(benzyloxy)carbonyl]amino}ethyl)-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]carbonyl}(isopropyl)amino]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3R)-3-[{[4-(2-{[(benzyloxy)carbonyl]amino}ethyl)-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]carbonyl}(isopropyl)amino]piperidine-1-carboxylate
CAS No.:1163281-56-8
Molecular Formula:C₃₅H₄₈N₄O₇
Molecular Weight:636.789
Hs Code.:

tert-butyl (3R)-3-[{[4-(2-{[(benzyloxy)carbonyl]amino}ethyl)-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]carbonyl}(isopropyl)amino]piperidine-1-carboxylate

Synonyms:tert-butyl (3R)-3-[{[4-(2-{[(benzyloxy)carbonyl]amino}ethyl)-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]carbonyl}(isopropyl)amino]piperidine-1-carboxylate

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Chemical Property of tert-butyl (3R)-3-[{[4-(2-{[(benzyloxy)carbonyl]amino}ethyl)-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]carbonyl}(isopropyl)amino]piperidine-1-carboxylate

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Technology Process of tert-butyl (3R)-3-[{[4-(2-{[(benzyloxy)carbonyl]amino}ethyl)-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]carbonyl}(isopropyl)amino]piperidine-1-carboxylate

There total 6 articles about tert-butyl (3R)-3-[{[4-(2-{[(benzyloxy)carbonyl]amino}ethyl)-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]carbonyl}(isopropyl)amino]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1044562-02-8,1163286-38-1
(R)-3-isopropylaminopiperidine-1-carboxylic acid tert-butyl ester

: 1259436-16-2
4-(2-{[(Benzyloxy)carbonyl]amino}ethyl)-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-1 ,4-benzoxazine-6-carboxylic acid

: 1163281-56-8
tert-butyl (3R)-3-[{[4-(2-{[(benzyloxy)carbonyl]amino}ethyl)-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]carbonyl}(isopropyl)amino]piperidine-1-carboxylate

Guidance literature:: 4-(2-{[(Benzyloxy)carbonyl]amino}ethyl)-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-1 ,4-benzoxazine-6-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

(R)-3-isopropylaminopiperidine-1-carboxylic acid tert-butyl ester; With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 53844-02-3
benzyl N-(2-bromoethyl)carbamate

: 1163281-56-8
tert-butyl (3R)-3-[{[4-(2-{[(benzyloxy)carbonyl]amino}ethyl)-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]carbonyl}(isopropyl)amino]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium iodide; caesium carbonate / N,N-dimethyl-formamide; acetonitrile / 5 h / 100 °C

2.1: sodium hydroxide; water / 1,4-dioxane; tetrahydrofuran / 5 h / 70 °C

2.2: pH 1

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

3.2: 2 h / 20 °C

With oxalyl dichloride; water; caesium carbonate; N,N-dimethyl-formamide; potassium iodide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1163281-56-8
tert-butyl (3R)-3-[{[4-(2-{[(benzyloxy)carbonyl]amino}ethyl)-2,2,7-trimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]carbonyl}(isopropyl)amino]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / chloroform / 0 - 20 °C / Cooling with ice

2.1: potassium iodide; caesium carbonate / N,N-dimethyl-formamide; acetonitrile / 5 h / 100 °C

3.1: sodium hydroxide; water / 1,4-dioxane; tetrahydrofuran / 5 h / 70 °C

3.2: pH 1

4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

4.2: 2 h / 20 °C

With oxalyl dichloride; water; caesium carbonate; triethylamine; N,N-dimethyl-formamide; potassium iodide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; N,N-dimethyl-formamide; acetonitrile;