(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide

Base Information

• Chemical Name: (3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide
• CAS No.: 1353644-70-8
• Molecular Formula: C₂₅H₂₆N₆O₂
• Molecular Weight: 442.52

Synonyms:(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide

Chemical Property of (3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Theliatinib(HMPL-309) >98% ^*data from reagent suppliers

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Technology Process of (3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide

There total 9 articles about (3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrole (1353644-77-5) + C24H18N4O3 (1203904-22-6) → (3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide (1353644-70-8)

Guidance literature:

With pyridine; In 1,4-dioxane; at 70 ℃; for 5h;

Reference yield:

(3aR,6aR)-N-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-formamide tartrate → (3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide (1353644-70-8)

Guidance literature:

With sodium carbonate; In ethanol; water; at 20 ℃; for 48h;

Reference yield:

(3aR,6aR)-N-(4-((1H-benzo[d][1,2,3]triazol-1-yl)oxy)-7-methoxyquinazoline-6 -yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide + hydrochloric salt of m-aminophenylacetylene (207226-02-6) → (3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide (1353644-70-8)

Guidance literature:

In N,N-dimethyl-formamide; at 50 - 60 ℃; for 22h;

upstream raw materials:

(3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrole

C₂₄H₁₈N₄O₃

hydrochloric salt of m-aminophenylacetylene

3-acetylenephenylamine

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