Amprotropine

Base Information

• Chemical Name: Amprotropine
• CAS No.: 148-32-3
• Molecular Formula: C₁₈H₂₉NO₃
• Molecular Weight: 307.433
• Hs Code.: 2922509090
• UNII: Q1S268DPRS
• DSSTox Substance ID: DTXSID90933277
• Nikkaji Number: J5.845I
• Wikidata: Q5673348,Q27105766
• NCI Thesaurus Code: C79938
• Metabolomics Workbench ID: 67569
• ChEMBL ID: CHEMBL4302313
• Mol file: 148-32-3.mol

Synonyms:amprotropine;amprotropine phosphate;Syntropan

Chemical Property of Amprotropine

Chemical Property:

• Vapor Pressure: 1.21E-07mmHg at 25°C
• Boiling Point: 415.3°Cat760mmHg
• Flash Point: 205°C
• PSA: 49.77000
• Density: g/cm³
• LogP: 2.67370
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 10
• Exact Mass: 307.21474379
• Heavy Atom Count: 22
• Complexity: 320

Purity/Quality:

98%min ^*data from raw suppliers

AMPROTROPINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CC(C)(C)COC(=O)C(CO)C1=CC=CC=C1

Technology Process of Amprotropine

There total 6 articles about Amprotropine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-N,N-diethyl-2,2-dimethylpropan-1-amine (54777-53-6) → (+/-)-tropic acid-(3-diethylamino-2,2-dimethyl-propyl ester) (148-32-3)

Guidance literature:

With benzene;

Reference yield:

3-chloro-N,N-diethyl-2,2-dimethylpropan-1-amine (54777-53-6) → (R)-tropic acid-(3-diethylamino-2,2-dimethyl-propyl ester) (148-32-3)

Guidance literature:

With acetone;

Reference yield:

(+/-)-3-acetoxy-2-phenyl-propionic acid-(3-diethylamino-2,2-dimethyl-propyl ester) → (+/-)-tropic acid-(3-diethylamino-2,2-dimethyl-propyl ester) (148-32-3)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

3-diethylamino-2,2-dimethylpropanol

(+)-(R)-tropic acid

acetyl chloride

3-chloro-N,N-diethyl-2,2-dimethylpropan-1-amine