2-benzoyloxy-1-(3-benzyloxy-4-methoxyphenyl)-2-<2-β-(N-ethoxycarbonyl-N-methyl)aminoethyl>-4,5-methylenedioxy-phenylethanone

Base Information

• Chemical Name: 2-benzoyloxy-1-(3-benzyloxy-4-methoxyphenyl)-2-<2-β-(N-ethoxycarbonyl-N-methyl)aminoethyl>-4,5-methylenedioxy-phenylethanone
• CAS No.: 124465-48-1
• Molecular Formula: C₃₆H₃₅NO₉
• Molecular Weight: 625.675
• Mol file: 124465-48-1.mol

Synonyms:2-benzoyloxy-1-(3-benzyloxy-4-methoxyphenyl)-2-<2-β-(N-ethoxycarbonyl-N-methyl)aminoethyl>-4,5-methylenedioxy-phenylethanone

Chemical Property of 2-benzoyloxy-1-(3-benzyloxy-4-methoxyphenyl)-2-<2-β-(N-ethoxycarbonyl-N-methyl)aminoethyl>-4,5-methylenedioxy-phenylethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzoyloxy-1-(3-benzyloxy-4-methoxyphenyl)-2-<2-β-(N-ethoxycarbonyl-N-methyl)aminoethyl>-4,5-methylenedioxy-phenylethanone

There total 2 articles about 2-benzoyloxy-1-(3-benzyloxy-4-methoxyphenyl)-2-<2-β-(N-ethoxycarbonyl-N-methyl)aminoethyl>-4,5-methylenedioxy-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

[2-(6-formyl-benzo[1,3]dioxol-5-yl)-ethyl]-methyl-carbamic acid ethyl ester (60229-32-5) + 2-benzoyloxy-2-(3'-benzyloxy-4'-methoxy)acetonitrile (124465-47-0) → 2-benzoyloxy-1-(3-benzyloxy-4-methoxyphenyl)-2-<2-β-(N-ethoxycarbonyl-N-methyl)aminoethyl>-4,5-methylenedioxy-phenylethanone (124465-48-1)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In benzene; for 5h; Ambient temperature;

Reference yield:

3-benzyloxy-4-methoxybenzaldehyde (6346-05-0) → 2-benzoyloxy-1-(3-benzyloxy-4-methoxyphenyl)-2-<2-β-(N-ethoxycarbonyl-N-methyl)aminoethyl>-4,5-methylenedioxy-phenylethanone (124465-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / CH₂Cl₂; H₂O / Ambient temperature

2: 91 percent / 50percent sodium hydroxide, TEBA / benzene / 5 h / Ambient temperature

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; water; benzene;

Reference yield:

2-benzoyloxy-1-(3-benzyloxy-4-methoxyphenyl)-2-<2-β-(N-ethoxycarbonyl-N-methyl)aminoethyl>-4,5-methylenedioxy-phenylethanone (124465-48-1) → cryptopleurospermine (27263-58-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / lithium aluminium hydride / tetrahydrofuran / 5 h / Ambient temperature

2: 1.) oxalyl chloride, DMSO, 2.) triethylamine / 1.) dichloromethane, -60 deg C, 15 min, 2.) dichloromethane, -60 deg C

3: 30 percent / 5percent aq. HCl / 10percent Pd/C / methanol

With hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;

upstream raw materials:

[2-(6-formyl-benzo[1,3]dioxol-5-yl)-ethyl]-methyl-carbamic acid ethyl ester

2-benzoyloxy-2-(3'-benzyloxy-4'-methoxy)acetonitrile

3-benzyloxy-4-methoxybenzaldehyde

Downstream raw materials:

cryptopleurospermine

(3-benzyloxy-4-methoxyphenyl)(2-β-<(N,N-dimethyl)aminoethyl>-4,5-methylenedioxyphenyl)-ethanedione