N-(4-chloro-phenyl)-2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide

Base Information

• Chemical Name: N-(4-chloro-phenyl)-2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide
• CAS No.: 345912-29-0
• Molecular Formula: C₂₄H₂₀ClN₃O₂S
• Molecular Weight: 449.961
• Mol file: 345912-29-0.mol

Synonyms:N-(4-chloro-phenyl)-2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide

Chemical Property of N-(4-chloro-phenyl)-2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide

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Technology Process of N-(4-chloro-phenyl)-2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide

There total 1 articles about N-(4-chloro-phenyl)-2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-chloro-N-(4-chlorophenyl)acetamide (3289-75-6) + 4-(4-methoxyphenyl)-2-sulfanylidene-1H,2H,5H,6H,7H-cyclopenta[b]pyridine-3-carbonitrile (120517-49-9) → N-(4-chloro-phenyl)-2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide (345912-29-0)

Guidance literature:

With sodium acetate; In ethanol; for 2h; Heating;

DOI:10.1080/10426500008076538

Reference yield: 93.0%

N-(4-chloro-phenyl)-2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide (345912-29-0) → 3-amino-4-(4-methoxy-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid (4-chloro-phenyl)-amide (345912-41-6)

Guidance literature:

With sodium ethanolate; In ethanol; for 0.0833333h; Heating;

DOI:10.1080/10426500008076538

Reference yield:

N-(4-chloro-phenyl)-2-[3-cyano-4-(4-methoxy-phenyl)-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl]-acetamide (345912-29-0) → 7-(4-chloro-phenyl)-4-(4-methoxy-phenyl)-2,3-dihydro-1H,7H-9-thia-5,7,10-triaza-cyclopenta[b]fluoren-8-one

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / EtONa / ethanol / 0.08 h / Heating

2: 90 percent / Ac₂O / 4 h / Heating

With sodium ethanolate; acetic anhydride; In ethanol; 1: Thorpe-Ziegler cyclization;

DOI:10.1080/10426500008076538

upstream raw materials:

2-chloro-N-(4-chlorophenyl)acetamide

4-(4-methoxyphenyl)-2-sulfanylidene-1H,2H,5H,6H,7H-cyclopenta[b]pyridine-3-carbonitrile

Downstream raw materials:

3-amino-4-(4-methoxy-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carboxylic acid (4-chloro-phenyl)-amide

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