Technology Process of (3R,4S,5S)-5-((S)-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-(methoxymethoxy)-3-methyldihydrofuran-2(3H)-one
There total 10 articles about (3R,4S,5S)-5-((S)-3-((4-methoxybenzyl)oxy)-2-methylpropyl)-4-(methoxymethoxy)-3-methyldihydrofuran-2(3H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridinium chlorochromate;
In
dichloromethane;
at 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/jo401480t
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
3.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane / 2 h / 20 °C / Molecular sieve; Inert atmosphere
4.1: tert.-butyl lithium; magnesium bromide / diethyl ether; pentane / 0.38 h / -78 °C / Inert atmosphere
4.2: 1.55 h / -78 °C / Inert atmosphere
5.1: ozone; triphenylphosphine; pyridine; Sudan III / methanol; dichloromethane / 12 h / -78 - 20 °C / Inert atmosphere
6.1: pyridinium chlorochromate / dichloromethane / 12 h / 20 °C / Inert atmosphere
With
pyridine; tetrapropylammonium perruthennate; tetrabutyl ammonium fluoride; tert.-butyl lithium; ozone; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; pyridinium chlorochromate; magnesium bromide; Sudan III;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; pentane;
3.1: |Parikh-Doering Oxidation;
DOI:10.1021/jo401480t
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tert.-butyl lithium; magnesium bromide / diethyl ether; pentane / 0.38 h / -78 °C / Inert atmosphere
1.2: 1.55 h / -78 °C / Inert atmosphere
2.1: ozone; triphenylphosphine; pyridine; Sudan III / methanol; dichloromethane / 12 h / -78 - 20 °C / Inert atmosphere
3.1: pyridinium chlorochromate / dichloromethane / 12 h / 20 °C / Inert atmosphere
With
pyridine; tert.-butyl lithium; ozone; triphenylphosphine; pyridinium chlorochromate; magnesium bromide; Sudan III;
In
methanol; diethyl ether; dichloromethane; pentane;
DOI:10.1021/jo401480t
