Bilirubin

Base Information Edit

Chemical Name:Bilirubin
CAS No.:635-65-4
Deprecated CAS:11053-42-2,114-24-9,19245-52-4,39372-61-7,493-86-7,55527-40-7,917-01-1,856927-39-4,1076199-07-9,188341-33-5,114-24-9,19245-52-4,39372-61-7,55527-40-7,856927-39-4,917-01-1
Molecular Formula:C33H36N4O6
Molecular Weight:584.672
Hs Code.:29339990
European Community (EC) Number:299-468-9,211-239-7
UNII:RFM9X3LJ49
DSSTox Substance ID:DTXSID8060905
Nikkaji Number:J60.126H,J674.476A
Wikipedia:Bilirubin
Wikidata:Q104219
NCI Thesaurus Code:C305
Pharos Ligand ID:9KRHBLJHVHYY
Metabolomics Workbench ID:37047
ChEMBL ID:CHEMBL501680
Mol file:635-65-4.mol

Synonyms:Bilirubin;Bilirubin IX alpha;Bilirubin, (15E)-Isomer;Bilirubin, (4E)-Isomer;Bilirubin, (4E,15E)-Isomer;Bilirubin, Calcium Salt;Bilirubin, Disodium Salt;Bilirubin, Monosodium Salt;Bilirubinate, Calcium;Calcium Bilirubinate;Calcium Salt Bilirubin;delta Bilirubin;delta-Bilirubin;Disodium Salt Bilirubin;Hematoidin;Monosodium Salt Bilirubin;Salt Bilirubin, Calcium

Suppliers and Price of Bilirubin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Bilirubin
25mg
$ 399.00

TRC
Bilirubin
5g
$ 400.00

Sigma-Aldrich
Bilirubin ≥98% (EmM/453 = 60), powder
5g
$ 1070.00

Sigma-Aldrich
Bilirubin - CAS 635-65-4 - Calbiochem Principal pigment of bile and one of the major end products of hemoglobin decomposition.
1 g
$ 195.17

Sigma-Aldrich
Bilirubin - CAS 635-65-4 - Calbiochem
1gm
$ 203.00

Sigma-Aldrich
Bilirubin ≥98% (EmM/453 = 60), powder
1g
$ 305.00

Matrix Scientific
3-{2-({3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl}methyl)-4-methyl-5-[(Z)-(4-methyl-5-ox
1g
$ 150.00

Matrix Scientific
3-{2-({3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylidene)methyl]-1H-pyrrol-2-yl}methyl)-4-methyl-5-[(Z)-(4-methyl-5-ox
0.500g
$ 120.00

DC Chemicals
Bilirubin >98%,StandardReferencesGrade
20 mg
$ 280.00

Crysdot
Bilirubin 97%
1g
$ 196.00

Total 183 raw suppliers

Chemical Property of Bilirubin Edit

Chemical Property:

Appearance/Colour:Light orange to deep redish-brown crystalline solid
Vapor Pressure:0mmHg at 25°C
Melting Point:192 °C
Refractive Index:1.6000 (estimate)
Boiling Point:925.157 °C at 760 mmHg
PKA:4.62±0.10(Predicted)
Flash Point:513.317 °C
PSA：164.38000
Density:1.374 g/cm³
LogP:5.18880
Storage Temp.:−20°C
Sensitive.:Light Sensitive
Solubility.:aqueous acid: soluble
Water Solubility.:practically insoluble
XLogP3:2.9
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:12
Exact Mass:584.26348488
Heavy Atom Count:43
Complexity:1340

Purity/Quality:

99%, ^*data from raw suppliers

Bilirubin ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 62-36/37/38-20/21/22
Safety Statements: 22-24/25-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Chemical Classes:Biological Agents -> Other Biomolecules
Canonical SMILES:CC1=C(NC(=C1CCC(=O)O)CC2=C(C(=C(N2)C=C3C(=C(C(=O)N3)C)C=C)C)CCC(=O)O)C=C4C(=C(C(=O)N4)C=C)C
Isomeric SMILES:CC1=C(NC(=C1CCC(=O)O)CC2=C(C(=C(N2)/C=C\3/C(=C(C(=O)N3)C)C=C)C)CCC(=O)O)/C=C\4/C(=C(C(=O)N4)C=C)C
Recent NIPH Clinical Trials:Prospective study about preventive drainage tube placement at laparoscopic liver resection(Randomized Controlled Trial)
Description Bilirubin is a yellow breakdown product of heme catabolism, formed when heme is cleaved by heme oxygenase. This reaction produces carbon monoxide and biliverdin, which is rapidly reduced to bilirubin by biliverdin reductase. Bilirubin has key roles as a free radical scavenger with antioxidant and anti-inflammatory actions. Free and albumin-bound bilirubin can also scavenge nitric oxide (NO) and NO-related species. Unconjugated bilirubin is highly water-insoluble and must be conjugated with glucuronides to become water soluble and subsequently excreted by the liver and kidney.
Uses Principal pigment of bile and constituent of many biliary calculi Bilirubin is widely utilized to monitor the liver function and their disease, such as hepatitis or cirrhosis; or the effects of medicines which are damage the liver. It acts as a pigment in certain algae to capture light energy. Its double bonds are isomerizes in the presence of light, which is employed in phototherapy of jaundiced newborns babies. It is used to detect the blocking in bile ducts. Bilirubin has been used:in phantom preparationin in vitro experimentsin the preparation of bilirubin solutions for infusion

Technology Process of Bilirubin

There total 12 articles about Bilirubin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 902268-70-6,493-89-0
biliverdin IXα

: 635-65-4,69853-42-5,69853-43-6,69853-44-7,148219-49-2,134733-79-2,134733-81-6,114-24-9
bilirubin IXα

Guidance literature:: With zinc(II) tetrahydroborate; tert-butylhydroquinone; In methanol; at 0 - 20 ℃; for 0.5h; Reagent/catalyst; Inert atmosphere;