6⁴,1⁴-diiodo-6³,5²,4³,3²,2³,1³-hexa(18-azacrown-6-N-carbonylmethoxy)-p-sexiphenyl

Base Information

• Chemical Name: 6⁴,1⁴-diiodo-6³,5²,4³,3²,2³,1³-hexa(18-azacrown-6-N-carbonylmethoxy)-p-sexiphenyl
• CAS No.: 256387-79-8
• Molecular Formula: C₁₂₀H₁₇₄I₂N₆O₄₂
• Molecular Weight: 2626.53
• Mol file: 256387-79-8.mol

Synonyms:6⁴,1⁴-diiodo-6³,5²,4³,3²,2³,1³-hexa(18-azacrown-6-N-carbonylmethoxy)-p-sexiphenyl

Chemical Property of 6⁴,1⁴-diiodo-6³,5²,4³,3²,2³,1³-hexa(18-azacrown-6-N-carbonylmethoxy)-p-sexiphenyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6⁴,1⁴-diiodo-6³,5²,4³,3²,2³,1³-hexa(18-azacrown-6-N-carbonylmethoxy)-p-sexiphenyl

There total 2 articles about 6⁴,1⁴-diiodo-6³,5²,4³,3²,2³,1³-hexa(18-azacrown-6-N-carbonylmethoxy)-p-sexiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-aza-18-crown-6 (33941-15-0) + (3,2',2''',2'''',3'''''-pentakis-carboxymethoxy-4,4'''''-diiodo-[1,4';1',1'';4'',4''';1''',1'''';4'''',1''''']sexiphenyl-2''-yloxy)-acetic acid → 64,14-diiodo-63,52,43,32,23,13-hexa(18-azacrown-6-N-carbonylmethoxy)-p-sexiphenyl (256387-79-8)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/ol991210n

Reference yield:

4,4'-diiodo-3,3'-di(18-azacrown-6-N-carbonylmethoxy)biphenyl (256387-74-3) + 2-[3'-[2-oxo-2-(1,4,7,10,13-pentaoxa-16-aza-cyclooctadec-16-yl)-ethoxy]-4,4'-bis-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-3-yloxy]-1-(1,4,7,10,13-pentaoxa-16-aza-cyclooctadec-16-yl)-ethanone → 64,14-diiodo-63,52,43,32,23,13-hexa(18-azacrown-6-N-carbonylmethoxy)-p-sexiphenyl (256387-79-8)

Guidance literature:

With potassium carbonate; thiophenol; In acetonitrile;

DOI:10.1002/(SICI)1521-3773(19991216)38:24<3684::AID-ANIE3684>3.0.CO;2-M

Reference yield: 40.0%

(4-thiomethoxyphenyl)boronic acid (98546-51-1) + 64,14-diiodo-63,52,43,32,23,13-hexa(18-azacrown-6-N-carbonylmethoxy)-p-sexiphenyl (256387-79-8) → 84,14-dimethylsulfanyl-73,62,53,42,33,22-hexa(18-azacrown-6-N-carbonylmethoxy)-p-octiphenyl (256387-82-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; toluene; for 18h; Heating;

DOI:10.1021/ol991210n

upstream raw materials:

1-aza-18-crown-6

4,4'-diiodo-3,3'-di(18-azacrown-6-N-carbonylmethoxy)biphenyl

Downstream raw materials:

8⁴,1⁴-dimethylsulfanyl-7³,6²,5³,4²,3³,2²-hexa(18-azacrown-6-N-carbonylmethoxy)-p-octiphenyl

1⁴-2'-t-Boc-aminoethylthio-8⁴-methylthio-7³,6²,5³,4²,3³,2²-hexa(18-aza-6-N-carbonylmethoxy)-p-octiphenyl