N-tert-butyloxycarbonyl-L-valyl-N_ε-benzyloxycarbonyl-L-lysyl-L-leucine methylester

Base Information

• Chemical Name: N-tert-butyloxycarbonyl-L-valyl-N_ε-benzyloxycarbonyl-L-lysyl-L-leucine methylester
• CAS No.: 150650-93-4
• Molecular Formula: C₃₁H₅₀N₄O₈
• Molecular Weight: 606.76

Synonyms:N-tert-butyloxycarbonyl-L-valyl-N_ε-benzyloxycarbonyl-L-lysyl-L-leucine methylester

Chemical Property of N-tert-butyloxycarbonyl-L-valyl-N_ε-benzyloxycarbonyl-L-lysyl-L-leucine methylester

Chemical Property:

Purity/Quality:

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Technology Process of N-tert-butyloxycarbonyl-L-valyl-N_ε-benzyloxycarbonyl-L-lysyl-L-leucine methylester

There total 2 articles about N-tert-butyloxycarbonyl-L-valyl-N_ε-benzyloxycarbonyl-L-lysyl-L-leucine methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butoxycarbonylvalyl-Nε-benzyloxycarbonyllysine (68455-55-0) → N-tert-butyloxycarbonyl-L-valyl-Nε-benzyloxycarbonyl-L-lysyl-L-leucine methylester (150650-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / tetrahydrofuran / 0.5 h / -15 °C

2: tetrahydrofuran / 2 h / -15 °C

With 4-methyl-morpholine; In tetrahydrofuran;

DOI:10.1016/0223-5234(93)90147-7

Reference yield:

methyl (L)-leucinate hydrochloride (7517-19-3) + C29H45N3O9 → N-tert-butyloxycarbonyl-L-valyl-Nε-benzyloxycarbonyl-L-lysyl-L-leucine methylester (150650-93-4)

Guidance literature:

In tetrahydrofuran; at -15 ℃; for 2h; Yield given;

DOI:10.1016/0223-5234(93)90147-7

Reference yield: 89.5%

N-tert-butyloxycarbonyl-L-valyl-Nε-benzyloxycarbonyl-L-lysyl-L-leucine methylester (150650-93-4) → N-tert-butyloxycarbonyl-L-valyl-Nε-benzyloxycarbonyl-L-lysyl-L-leucyl hydrazine (150650-97-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 96h; Ambient temperature;

DOI:10.1016/0223-5234(93)90147-7

upstream raw materials:

methyl (L)-leucinate hydrochloride

tert-butoxycarbonylvalyl-N^ε-benzyloxycarbonyllysine

Downstream raw materials:

N-tert-butyloxycarbonyl-L-valyl-N_ε-benzyloxycarbonyl-L-lysyl-L-leucyl hydrazine

N-tert-butyloxycarbonyl-L-valyl-N_ε-tosyl-L-lysyl-L-leucine methylester

1-(N-tert-butyloxycarbonyl-L-valyl-N_ε-methyloxycarbonyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzyl) hydrazine

1-(N-tert-butyloxycarbonyl-L-valyl-N_ε-methyloxycarbonyl-L-lysyl-L-leucyl)-2-(4-hydroxybenzal) hydrazone

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