2'-(tert-butyldimethylsilyl)-4-deacetyl-4-methoxycarbonyl-7-(triethylsilyl)-5,20-deoxy-5,20-sulfinylpaclitaxel

Base Information

Chemical Name:2'-(tert-butyldimethylsilyl)-4-deacetyl-4-methoxycarbonyl-7-(triethylsilyl)-5,20-deoxy-5,20-sulfinylpaclitaxel
CAS No.:225660-88-8
Molecular Formula:C₅₉H₇₉NO₁₄SSi₂
Molecular Weight:1114.51
Hs Code.:

Synonyms:2'-(tert-butyldimethylsilyl)-4-deacetyl-4-methoxycarbonyl-7-(triethylsilyl)-5,20-deoxy-5,20-sulfinylpaclitaxel

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-(tert-butyldimethylsilyl)-4-deacetyl-4-methoxycarbonyl-7-(triethylsilyl)-5,20-deoxy-5,20-sulfinylpaclitaxel

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Technology Process of 2'-(tert-butyldimethylsilyl)-4-deacetyl-4-methoxycarbonyl-7-(triethylsilyl)-5,20-deoxy-5,20-sulfinylpaclitaxel

There total 2 articles about 2'-(tert-butyldimethylsilyl)-4-deacetyl-4-methoxycarbonyl-7-(triethylsilyl)-5,20-deoxy-5,20-sulfinylpaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 591-51-5
phenyllithium

: 225660-87-7
2'-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-4-methoxycarbonyl-7-(triethylsilyl)-5,20-deoxy-5,20-sulfinylpaclitaxel 1,2-carbonate

: 225660-88-8
2'-(tert-butyldimethylsilyl)-4-deacetyl-4-methoxycarbonyl-7-(triethylsilyl)-5,20-deoxy-5,20-sulfinylpaclitaxel

Guidance literature:: In tetrahydrofuran; diethyl ether; cyclohexane; at -78 ℃; for 0.05h;
DOI:10.1021/jo982095h

Reference yield:

: 225660-84-4
2'-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-7-(triethylsilyl)-5,20-deoxy-5,20-sulfinylpaclitaxel 1,2-carbonate

: 225660-88-8
2'-(tert-butyldimethylsilyl)-4-deacetyl-4-methoxycarbonyl-7-(triethylsilyl)-5,20-deoxy-5,20-sulfinylpaclitaxel

Guidance literature:: Multi-step reaction with 2 steps

1: 39 percent / LHMDS / tetrahydrofuran / -78 °C

2: 61 percent / tetrahydrofuran; cyclohexane; diethyl ether / 0.05 h / -78 °C

With lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; cyclohexane;
DOI:10.1021/jo982095h