C₅₆H₇₆N₄O₁₄Si₂

Base Information

• Chemical Name: C₅₆H₇₆N₄O₁₄Si₂
• CAS No.: 1346575-94-7
• Molecular Formula: C₅₆H₇₆N₄O₁₄Si₂
• Molecular Weight: 1085.41
• Mol file: 1346575-94-7.mol

Synonyms:C₅₆H₇₆N₄O₁₄Si₂

Chemical Property of C₅₆H₇₆N₄O₁₄Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₆H₇₆N₄O₁₄Si₂

There total 10 articles about C₅₆H₇₆N₄O₁₄Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-O-(t-butyldimethylsilyl)-2-debenzoyl-2-m-N3-10-O-trimethylsilyl-10-deacetylcephalomannine (1346571-55-8) + cyclopropanecarboxylic acid (1759-53-1) → C56H76N4O14Si2 (1346575-94-7)

Guidance literature:

cyclopropanecarboxylic acid; With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; In toluene; at 20 ℃; for 0.0833333h; Inert atmosphere;

2'-O-(t-butyldimethylsilyl)-2-debenzoyl-2-m-N₃-10-O-trimethylsilyl-10-deacetylcephalomannine; In toluene; at 65 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.06.034

Reference yield:

C51H67NO14Si (944454-50-6) → C56H76N4O14Si2 (1346575-94-7)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2.1: N-benzyl-trimethylammonium hydroxide / methanol; dichloromethane / -65 - -10 °C / Inert atmosphere

3.1: 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide / toluene / 13 h / 65 °C / Inert atmosphere

4.1: pyridine; hydrogen fluoride / water; acetonitrile / 20 °C

5.1: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 40 °C / Inert atmosphere

6.1: hydrazine hydrate / ethanol; water / 10 h / -20 - 0 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -20 °C / Inert atmosphere

8.1: 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide / toluene / 0.08 h / 20 °C / Inert atmosphere

8.2: 65 °C / Inert atmosphere

With pyridine; 1H-imidazole; hydrogen fluoride; N-benzyl-trimethylammonium hydroxide; 4-pyrrolidin-1-ylpyridine; hydrazine hydrate; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1016/j.bmcl.2011.06.034

Reference yield:

2'-O-(t-butyldimethylsilyl)-2-debenzoyl-2-m-N3-benzoyl-10-deacetylcephalomannine (1329497-59-7) → C56H76N4O14Si2 (1346575-94-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -20 °C / Inert atmosphere

2.1: 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide / toluene / 0.08 h / 20 °C / Inert atmosphere

2.2: 65 °C / Inert atmosphere

With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;

DOI:10.1016/j.bmcl.2011.06.034

upstream raw materials:

C₅₁H₆₇NO₁₄Si

2'-O-(t-butyldimethylsilyl)-2-debenzoyl-2-m-N₃-benzoyl-10-deacetylcephalomannine

2'-O-(t-butyldimethylsilyl)-2-debenzoyl-2-m-N₃-10-O-trimethylsilyl-10-deacetylcephalomannine

cyclopropanecarboxylic acid

Downstream raw materials:

C₄₇H₅₄N₄O₁₄