5'-O-dimethoxytrityl-N₁-(1-pyreneacetylamino)-2'-deoxyinosine

Base Information

• Chemical Name: 5'-O-dimethoxytrityl-N₁-(1-pyreneacetylamino)-2'-deoxyinosine
• CAS No.: 527720-94-1
• Molecular Formula: C₄₉H₄₁N₅O₇
• Molecular Weight: 811.894
• Mol file: 527720-94-1.mol

Synonyms:5'-O-dimethoxytrityl-N₁-(1-pyreneacetylamino)-2'-deoxyinosine

Chemical Property of 5'-O-dimethoxytrityl-N₁-(1-pyreneacetylamino)-2'-deoxyinosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-dimethoxytrityl-N₁-(1-pyreneacetylamino)-2'-deoxyinosine

There total 3 articles about 5'-O-dimethoxytrityl-N₁-(1-pyreneacetylamino)-2'-deoxyinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-pyreneacetic acid (64709-55-3) + 5'-O-dimethoxytrityl-1-amino-2'-deoxyinosine (527720-90-7) → 5'-O-dimethoxytrityl-N1-(1-pyreneacetylamino)-2'-deoxyinosine (527720-94-1)

Guidance literature:

With hydrogenchloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tetlet.2003.11.144

Reference yield:

9-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one (93778-57-5) → 5'-O-dimethoxytrityl-N1-(1-pyreneacetylamino)-2'-deoxyinosine (527720-94-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / K₂CO₃ / dimethylformamide / 0.5 h / 80 °C

2: 55 percent / NH₂NH₂; K₂CO₃ / H₂O; acetonitrile / 2 h / 20 °C

3: 73 percent / 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide; HCl / dimethylformamide / 20 °C

With hydrogenchloride; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; hydrazine; In water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tetlet.2003.11.144

Reference yield:

5'-O-dimethoxytrityl-1-(2,4-dinitrophenyl)-2'-deoxyinosine (527720-88-3) → 5'-O-dimethoxytrityl-N1-(1-pyreneacetylamino)-2'-deoxyinosine (527720-94-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / NH₂NH₂; K₂CO₃ / H₂O; acetonitrile / 2 h / 20 °C

2: 73 percent / 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide; HCl / dimethylformamide / 20 °C

With hydrogenchloride; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; hydrazine; In water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tetlet.2003.11.144

upstream raw materials:

1-pyreneacetic acid

5'-O-dimethoxytrityl-1-amino-2'-deoxyinosine

9-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one

5'-O-dimethoxytrityl-1-(2,4-dinitrophenyl)-2'-deoxyinosine