N-trans-{4-[2-(4-benzo[1,3]dioxol-4-ylpiperazin-1-yl)ethyl]cyclohexyl}-2-fluoroacetamide

Base Information

Chemical Name:N-trans-{4-[2-(4-benzo[1,3]dioxol-4-ylpiperazin-1-yl)ethyl]cyclohexyl}-2-fluoroacetamide
CAS No.:1394036-68-0
Molecular Formula:C₂₁H₃₀FN₃O₃
Molecular Weight:391.486
Hs Code.:

Synonyms:N-trans-{4-[2-(4-benzo[1,3]dioxol-4-ylpiperazin-1-yl)ethyl]cyclohexyl}-2-fluoroacetamide

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Chemical Property of N-trans-{4-[2-(4-benzo[1,3]dioxol-4-ylpiperazin-1-yl)ethyl]cyclohexyl}-2-fluoroacetamide

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Technology Process of N-trans-{4-[2-(4-benzo[1,3]dioxol-4-ylpiperazin-1-yl)ethyl]cyclohexyl}-2-fluoroacetamide

There total 3 articles about N-trans-{4-[2-(4-benzo[1,3]dioxol-4-ylpiperazin-1-yl)ethyl]cyclohexyl}-2-fluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.9%

: 453-18-9
methyl fluoroacetate

: trans-4-[2-(4-benzo[1,3]dioxol-4-ylpiperazin-1-yl)ethyl]cyclohexylamine hydrochloride

: 1394036-68-0
N-trans-{4-[2-(4-benzo[1,3]dioxol-4-ylpiperazin-1-yl)ethyl]cyclohexyl}-2-fluoroacetamide

Guidance literature:: methyl fluoroacetate; With potassium trimethylsilonate; In 1,4-dioxane; at 20 ℃;

trans-4-[2-(4-benzo[1,3]dioxol-4-ylpiperazin-1-yl)ethyl]cyclohexylamine hydrochloride; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield:

: 215790-29-7
1,1-dimethylethyl[trans-4-(2-oxoethyl)cyclohexyl]carbamate

: 1394036-68-0
N-trans-{4-[2-(4-benzo[1,3]dioxol-4-ylpiperazin-1-yl)ethyl]cyclohexyl}-2-fluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane; methanol / 2 h / 20 °C

1.2: 16 h / 20 °C

2.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

3.1: potassium trimethylsilonate / 1,4-dioxane / 20 °C

3.2: 4 h / 20 °C

With hydrogenchloride; potassium trimethylsilonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 1417564-98-7
trans-{4-[2-(4-benzo[1,3]dioxol-4-yl-piperazin-1-yl)ethyl]cyclohexyl}carbamic acid tert-butyl ester

: 1394036-68-0
N-trans-{4-[2-(4-benzo[1,3]dioxol-4-ylpiperazin-1-yl)ethyl]cyclohexyl}-2-fluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

2.1: potassium trimethylsilonate / 1,4-dioxane / 20 °C

2.2: 4 h / 20 °C

With hydrogenchloride; potassium trimethylsilonate; In 1,4-dioxane; dichloromethane;